Cholesterol Pills Review

Review of the best according to the editors. About the selection criteria. The the material is subjective, is not advertising and is not serves as a guide to the purchase. Before purchase is needed consultation with a specialist.

Many people find that lowering cholesterol with pills diet, or recommendations for a healthy lifestyle is an independent goal: cholesterol must be in the set, normal limits. Cholesterol really is “good” and “bad” and “bad” cholesterol is gradually deposited in the lumen blood vessels, forms plaques that cause elevated the risk of developing vascular accidents – heart attack and stroke.

But taking cholesterol-lowering drugs, or lipid-lowering drugs, primarily shown not only for normal cholesterol, and for the so-called secondary prophylaxis in patients with myocardial infarction. Before of all, these medicines are needed in order to prevent repeated heart attack. There are many reliable clinical studies in which was identified by hundreds of thousands of volunteers, which is a long the use of drugs from the statin group reduce the risk of mortality after a previous heart attack by at least 30%. This is really about long-term use, for 3 or 5 years.

Of course, high blood cholesterol, or hypercholesterolemia is a risk factor not only for a heart attack or coronary heart disease. It contributes to obesity, high blood pressure, increases the risk of diabetes and pancreatitis.

It is important that prescribing drugs to reduce cholesterol should only a doctor, and standard tactics must be followed. Initially, a patient with an increased risk of heart attack and stroke must follow dietary recommendations, change your lifestyle, give up bad habits, and only with inefficiency of all these measures and is prescribed therapy.

Achieving level targets is very important. total cholesterol. As an example, healthy a person should have a total cholesterol lower than 6.2 mmol / l. In patients with coronary heart disease, the target the level, that is, the concentration of cholesterol in the blood plasma, which must be achieved by prescribing medication, should be below 5 mmol / l.

It is reliably proven that prolonged use of statins in indications and achievement of target values ​​of total cholesterol and its fractions can reduce the risk of heart attacks, strokes, and sudden cardiac death. This rating includes the most modern, and effective cholesterol pills. it lipid-lowering drugs from the group of statins, fibrates and sequestrants of bile acids.

Cholesterol Pills Review

Nomination a place Name of product price
Modern statins to lower cholesterol 1 Rosuvastatin – Crestor (Rosucard, Rosulip, Tevastor) 583 rub
2 Atorvastatin – Liprimar (Tulip, Torvacard, Atoris) 226 r
3 Fluvastatin – Leskol Forte 1 750 rub.
drugs of other groups to reduce cholesterol 1 Ezetrol (ezetemib) 1 695 rub.
2 Omacor 1 546 rub.
3 Lipantil (fenofibrate) 906 r

Modern statins to lower cholesterol

Several generations of statins are currently known. And although several classes of drugs lower cholesterol, namely statins lead in the number of appointments worldwide. They all act according to one mechanism, they inhibit a particular enzyme, which is called “HMG-CoA reductase”. It works in the liver, and engaged in the synthesis of cholesterol. First, consider the modern remedy for cholesterol is the last, fourth statin generations.

Rosuvastatin – Crestor (Rosucard, Rosulip, Tevastor)

Popularity Rating: 4.9

Rosucard

The drug Crestor is indicated for all patients to achieve the target. cholesterol values ​​that have a high degree of risk of developing vascular catastrophes. These patients include individuals with arterial hypertension, diabetes mellitus, coronary artery disease hearts. There are certain conditions: before taking the drug the patient must prove that he can modify his diet and follow a diet aimed at lowering cholesterol. Does not have it makes no sense to take medication if the patient is not adheres to a diet, and consumes a large number of sources cholesterol with food. Therefore, all drugs to lower cholesterol require a diet.

The standard dosage of Crestor is 5 to 10 mg per day, and the initial dose depends on the initial concentration of cholesterol. You can increase the dose only after a month. Maximum daily the dose is 40 mg per day. Do not chew the tablet, and take it can be at any time of the day without regard to food intake.

The English company Astra Zeneca produces Krestor, and the packaging, with a minimum dosage (5 mg tablet) will cost 1835 rubles for 28 tablets. This is the minimum cost of a monthly course. original drug. Given that quite often required a gradual increase in dose, then you can cite the example of others numbers. The same package four times higher dosage, in 0.02 g will cost 3925 rubles, it is also designed for one month reception. There are cheaper options. So packaging Rosart (Actavis) costs 535 rubles, the same 28 tablets of 5 mg

Advantages and disadvantages

The advantage of the drug is high activity and proven efficiency. In the elderly, no dose adjustment is required, and usually this fact must be taken into account when prescribing many drugs for the elderly. You can also not change dosage for mild manifestations of renal failure.

Although Krestor has proven many studies. high efficiency, but he has contraindications. it concomitant treatment with cyclosporine, pregnancy and the period of chest feeding, the presence of various myopathies, and drinking. With caution, you can use Crestor with reduced function thyroid gland, as well as other severe endocrine disorders and epilepsy. However, with all the shortcomings Krestor – it is one of the most effective and modern drugs to reduce risk of sudden death and vascular catastrophes.

Atorvastatin – Liprimar (Tulip, Torvacard, Atoris)

Popularity Rating: 4.8

Tulip

Liprimar is a highly effective cholesterol pill, but they relate not to the fourth, but to the third, previous generation statins. The active substance is atorvastatin. Main difference between the fourth and third generation of statins is that drugs third generation just work well and reduce the amount “bad” cholesterol, but drugs of 4 generations, such as Crestor described above, while still contributing to the increase blood concentrations of “good” cholesterol. But Liprimar – high quality and original drug.

It is available in four dosages: 10, 20, 40 and 80 mg. Shown it is suitable for use with elevated levels of “bad” cholesterol – with hypercholesterolemia of different genesis, in complex prevention myocardial infarction and coronary heart disease in patients with high risk, while referring to both primary and secondary prevention.

Liprimar is used, like Krestor, once a day, at any time and regardless of meals. Dosage may vary significantly: from 10 to 80 mg, while the maximum dosage is 80 mg per day. Most often begin treatment with the minimum dose of 10 mg per day, increase the dose gradually and only as prescribed by the doctor. Liprimar is cheaper than Krestor. Pack of 30 tablets, with a minimum dosage of 10 mg, calculated on a monthly course, can be found in pharmacies from 350 rubles, and the average price is 717 rubles per package. Releases Liprimar is a well-known pharmaceutical company Pfizer.

There are many, much more affordable analogues. Liprimara, including domestic atorvastatin. Yes sir the same packaging, only produced by the Irbit Chemical Farm, will cost, on average 135 rubles. for packaging, but if desired can be found in pharmacies and at a price even cheaper than 60 rubles.

Advantages and disadvantages

The great advantage of Liprimar is its good knowledge and international experience, high efficiency, convenient use one once a day, and the ability to flexibly approach the change in dosage. However, there are a large number of contraindications, side effects and special conditions, which include numerous interactions of atorvastatin with other drugs. So, you can not prescribe Liprimar with a high level of hepatic enzymes, pregnant women and breast-feeding, people under 18 years old, as well as patients with severe impaired renal function thyroid function and with various muscle diseases.

Side effects such as headache are quite common. sore throat, constipation and bloating, various pains in muscles and joints, increased liver enzymes, allergies and even increased blood sugar. Liprimar interacts with a large the number of different drugs, so it is necessary to prescribe it should the doctor, as well as monitor the treatment. But this one the drug, being prescribed according to the indications by a specialist, taking into account all contraindications, performs its job well and reduces the risk occurrence of heart catastrophes.

Fluvastatin – Leskol Forte

Popularity Rating: 4.8

Fluvastatin

Leskol forte is a highly effective drug to lower cholesterol. It is indicated for patients with coronary heart disease, with the goal of primary and secondary prevention of myocardial infarction, with high levels of poor cholesterol, including those related to family cases hypercholesterolemia. Leskol can be used as monotherapy, that is, in addition to him, no additional drugs not required.

One tablet contains 80 mg of fluvastatin, and from this tablet the drug is released slowly, which allows you to create uniform plasma concentration without hesitation night time, this explains its high cost. Maximum the effect of its appointment develops in a month, then it’s possible review the prescribed dosage and change it aside increase. Before starting treatment, the patient should be on a diet aimed at lowering cholesterol, and adhere to this diet need throughout the course of treatment. Releases this drug pharmaceutical company Novartis, and the cost of one package in 28 tablets, calculated for one month, averages 2800 rubles.

Advantages and disadvantages

The advantage of Leskol is its high quality, proven efficiency, sustained release, which does not allow fluctuations in concentration, as well as a lasting effect after withdrawal the drug. But Leskol is contraindicated in pregnant and lactating women, in the presence of active pathological processes in the liver, which accompanied by increased activity of liver enzymes. There are some side effects. Often such symptoms like headache, abdominal discomfort, nausea. Despite for high efficiency, it is necessary during the course of treatment through every three months to assess the state of hepatic enzymes, with using biochemical blood tests. This is done to monitoring the liver against the background of the prescribed drug.

Also, before starting treatment, you must make sure that the patient there is no hypothyroidism, hereditary muscle diseases, and it does not abuses alcohol. In the event that everything is taken into account, and treatment controlled by a cardiologist, this drug will help in many cases, the patient gets rid of “bad cholesterol”, heart attacks, strokes and progression of coronary heart disease.

Overview of drugs from other groups to reduce cholesterol

Statins were isolated and reviewed separately because prescribed most often. But besides statins, there are others groups of drugs that reduce the amount of unwanted plasma cholesterol. This is nicotinic acid, ion exchange resins such as cholestyramine, fibroic derivatives acids to which clofibrate belong. Consider some funds that are often prescribed by doctors in complex therapy hypercholesterolemia in patients with high cardiac risk.

Ezetrol (ezetemib)

Popularity Rating: 4.9

Ezetrol

Ezetrol is a drug that lowers bad cholesterol in blood plasma by a different mechanism. It does not affect enzymes liver, and prevents the absorption of cholesterol from food in the intestines. Thus, cholesterol is gradually depleted in the liver after the appointment of Ezetrol, and then its concentration drops and in blood. This medication is indicated for the treatment of atherosclerosis, hypercholesterolemia, and can be used both independently and together with statins under the supervision of a physician. But the main indication is severe hypercholesterolemia that is genetically inherited and manifests itself in various family cases.

Ezetrol is prescribed at any time of the day, regardless of the meal. The initial dosage of Ezetrol is 10 mg once daily. The cost of one package of 28 tablets, calculated per month the rate is an average of 2000 rubles, and produces Ezetrol well-known pharmaceutical company Schering-Plow. Numerous generics of this drug have not yet been identified.

Advantages and disadvantages

The advantage of Ezetrol will be a unique mechanism of action, good tolerance. Undesirable effects were mild, and often passed without dosage adjustment and without canceling treatment. Often of the side effects there was a headache, and discomfort in the stomach. Ezetrol may be contraindicated in severe hepatic insufficiency, with increased sensitivity to components, and it is also impossible to simultaneously use this drug with a drug from groups of fibrates.

Ezetrol is not recommended for use in pregnant and lactating women, but only for the reason that no studies have been conducted, but this is a very sufficient argument for discontinuing the drug in case of pregnancy. But Ezetrol can be applied together with statins, and then the speed of the onset of targeted cholesterol levels are significantly higher than when prescribed separate treatment. However, even if Ezetrol is prescribed the patient must follow a diet aimed at reducing the amount of cholesterol supplied with food.

Omacor

Popularity Rating: 4.8

Omacor

Omacor lowers bad plasma cholesterol completely different way. These are no longer tablets, but soft gelatin capsules, with it is transparent and contains a light yellow greasy liquid. The active substance of Omacor is Omega – 3 unsaturated acids, namely a mixture of ethyl esters of two representatives of these acids.

Additionally, vitamin E, or alpha tocopherol, which is fat soluble. Omacor affects very low density lipoprotein concentration (VLDL), and reduces their number. It reduces the concentration of free fatty acids, and numerous research results have shown that those patients who regularly took one capsule of Omacor daily for 3.5 years, showed a decrease in overall mortality, as well as less frequent myocardial infarction and strokes.

Omacor is used as a means for the prevention of heart attack, with high cholesterol as a supplement to the drug therapy. Omacor can be used independently, without appointment drugs from the group of statins. But at the same time, the patient again must first start observing hypocholesterolemic a diet. Launches Omacor pharmaceutical company Banner Pharma, located in Germany and the Netherlands, and one pack of 28 capsules, designed for a monthly intake, will cost a pharmacy in 1657 rubles.

Advantages and disadvantages

Omacor’s big plus is the flexibility of prescribing: in patients with low cholesterol, he can be prescribed alone, and in the case of severe hypercholesterolemia, it is used in conjunction with statins. Omacor has proven effectiveness and is well tolerated. It will be contraindicated only during pregnancy, lactation and sensitivity to the components of the drug. Omacor is contraindicated in significant intake of triglycerides with food.

Nevertheless, it must be carefully prescribed in persons under 18 years of age, in old age, and in patients with severe hepatic impairment and the kidneys. Special medical supervision is also required in case of applications along with fibrates. Of the side effects more often various dyspeptic phenomena, such as discomfort in the abdomen and bloating. Omacor is good, reliable, auxiliary agent for the treatment of any stage hypercholesterolemia: from severe familial form in the composition complex therapy, and to easy.

Lipantil (fenofibrate)

Popularity Rating: 4.7

Lipantil

Fenofibrate refers to derivatives of fibroic acid, and reduces the concentration of triglycerides in the blood, and lipoproteins are very low density, which, in the end, are transformed into “bad” cholesterol. This drug is available in capsules, in each capsule – 200 mg of fenofibrate. This is a means of influencing the exchange. triglycerides. As a result of its use, the synthesis of fatty acids and cholesterol concentration decreases. Also Lipantil improves blood flow, and slightly lowers the concentration of sugar in plasma, therefore, may be prescribed in patients with sugar diabetes.

Studies show that Lipantil lowers total cholesterol. 25%, and it is indicated in the complex treatment of hypercholesterolemia, which is not amenable to diet correction. Lipantil is prescribed together with food, one capsule per day. The duration of the course is determined a doctor. The French company Ripharm produces Lipantil, and the packaging of 30 capsules, calculated on a monthly course, costs, on average, 1000 rubles.

Advantages and disadvantages

Lipantil is contraindicated in the pathology of muscle tissue, including hereditary, with severe damage to the liver and kidneys, and also with intolerance to fibrates. It is not used in children under 18 years, in pregnant and lactating mothers, in patients with deficiency lactases. The drug is well tolerated, but it should be prescribed by a doctor, because if in the form of self-medication it is combined with statins, there may be complications in muscle tissue. If the patient is applying Warfarin after a heart attack or stroke, or other anticoagulants, there may be a risk of bleeding. Lipantil cannot be prescribed with monoamine oxidase inhibitors (MAOs). All these precautions, if applied in a timely manner, and including control the level of hepatic enzymes in blood serum during treatment, allow to achieve a pronounced decrease cholesterol.

Conclusion

In conclusion, one important, but very simple thing to say. The modern pharmaceutical industry produces a large the amount of expensive and cheap drugs to reduce levels cholesterol, their intake, according to the results of numerous studies, significantly increases life expectancy and reduces risk occurrence of vascular accidents. But in each case apply the drug must be prepared, and patient preparation is reduced to lifestyle changes, giving up bad habits, and most the main thing is to follow a diet with a low content cholesterol.

This should be remembered to anyone who thinks that taking pills can replace the diet. You can’t replace the diet with pills, and decrease mortality risk and increased life expectancy reliably appeared only when the patient not only took drugs, but also consciously worked on their own diet.

This must be remembered, and you should not waste money in vain. Only in if the patient is on a diet for at least three weeks or months and he has no changes in the analyzes cholesterol, it is necessary to connect drugs. If a if the diet bears fruit, then you need to continue it until until cholesterol stops lowering. And if he does not reach targets on a diet, then only need to connect drugs included in the rating.

Popularity rating based on analysis of demand data service wordstat.yandex.ru.


Attention! This rating is subjective, not advertising and does not serve as a guide to the purchase. Before the purchase consultation with a specialist is necessary.

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