10 popular nootropic drugs

Review of the best according to the editors. About the selection criteria. The the material is subjective, is not advertising and is not serves as a guide to the purchase. Before purchase is needed consultation with a specialist.

In medicine, there are drugs that perform specific function (for example, destroy microbes, lower blood pressure, reduce fluid secretion into the lumen intestines). But there is a whole group of tools that allow improve body functions that are difficult to accurately statistics and measurement. It is about the so-called higher mental functions. Concepts such as mental activity, learning ability, brain resistance to harmful influences – are multifaceted and complex.

That is why drugs to improve higher nervous activities are so mixed by the public. There is no doubt that a number of these drugs allow improve the metabolism of neurons, their digestibility of glucose, improve the condition of their cell membranes, reduce their need for oxygen. It is believed that nootropic drugs (nootropics) are capable of improve learning and memory, give clarity of consciousness and “tenacity to attention”, allow to reduce the exhaustion of the nervous systems and increase the time ability to work actively.

Nootropic drugs also increase activity attention and thinking, improve speech. In some cases, they activate and have an antidepressant effect, and some of these remedies, on the contrary, soothe, reduce irritability, and contribute to a decrease in convulsive activity of the brain.

Such a multifaceted and wide field of activity for nootropic drugs allowed them to be prescribed in domestic medicine at the most different diseases and conditions. This is dementia and parkinsonism, consequences of neuroinfections and traumatic brain injury, decrease concentration and fatigue in healthy people during intense study sessions, chronic alcoholism and neurosis. Finally, nootropic tablets are taken to improve quality. sleep, and just for prevention in view of the upcoming active mental stress.

Nootropics are also widely used in pediatric practice. In our country, they are first-line drugs, and are included in the review of the means by which delayed speech and mental development, consequences of perinatal trauma, used in complex therapy in the treatment of cerebral palsy and in the treatment mild forms of mental retardation.

From a Western perspective, evidence-based medicine that requires quantification of effectiveness, in practice everything is far from so simple, but we will talk about this at the end of our review. And now the most Nootropic drugs popular and sold in Russia funds that are mainly produced in tablets.

Review of nootropic drugs

Nomination a place Name of product price
Review of nootropic drugs 1 Piracetam (Lucetam, Nootropil, Memotropil) 270 rub
2 Phenotropil (Phenylpiracetam, Carphedon) 519 rub
3 Encephabol 988 rub
4 Glycine 50 rub
5 Semax 391 rub
6 Cerebrolysin 1 100 rub.
7 Cortexin 837 rub
8 Mexidol (Mexiprim) 290 rub
9 Cytoflavin 472 rub
10 Pantogam 414 r

Piracetam (Lucetam, Nootropil, Memotropil)

Popularity Rating: 4.9

Nootropil

Opens Pills Review for Improving Mental Ability the most famous of the old nootropics, namely Piracetam. how according to the official instructions for use, Piracetam shown with almost 50 different diagnoses and conditions, ranging from mental retardation and cerebral infarction, and ending just old age and vascular dementia, such a volume in itself is doubtful. In its chemical structure, Piracetam is a derivative of gamma-aminobutyric acid.

We can assume that Piracetam is practically used in Russia with any problems associated with higher nervous activity, and it is contraindicated only with hypersensitivity, with chorea Huntington, and in children under 3 years. Restriction for use for this nootropic agent can be considered intracerebral history of hemorrhage or hemorrhagic stroke, administration anticoagulants and chronic renal failure.

This nootropic is used in tablets inside, as well as intramuscularly. Piracetam is available in 400 mg capsules, packings are very different – from 10 capsules to 200. At the beginning of treatment 2 capsules are prescribed 3 times a day before meals, then gradually reduce the dose by half, to one tablet three times a day. You should focus on a daily dose not exceeding 160 mg per kilogram of body weight. Produces very large quantities of piracetam domestic and foreign companies, and the cheapest pills are possible purchase already for 30 rub., 20 capsules

Advantages and disadvantages

The disadvantages of the Piracetam nootropic include the fact (but very important) that after many years of use in the USA Food and Drug Quality Control drugs (FDA) struck him off the drug list and lowered him status before dietary supplements, in the absence of evidence-based effectiveness. The advantages of a nootropic include good portability, ease of release form, inexpensive cost, and the presence in almost every Russian pharmacy, which is not guarantees nothing in terms of efficiency.

Phenotropil (Phenylpiracetam, Carphedon)

Popularity Rating: 4.8

Phenotropil

Phenotropil is also a “record holder” according to indications: official The instruction lists about 60 conditions and diagnoses. It turns out this nootropic agent is used for obesity and dementia, with schizophrenia with alcoholism, with depression and with illness Parkinson’s, with epilepsy and even with multiple sclerosis, convulsions, intracranial injuries and in connection with problems, related to adaptation to lifestyle changes. In other words, if the doctor advised you to stop drinking and smoking, then this will already be indications for the appointment of phenotropil. This medicine itself, by manufacturer’s statement, has anticonvulsant, nootropic, antiastenic and neuromodulatory effects, and take it need after a meal in a dose of 100 to 250 mg. Adults and healthy people for prevention purposes – you need 100 or 200 mg in the morning. This remedy is not recommended to be taken after 15:00 in connection with its activating action and possible worsening of sleep. 100 mg tablets produces nootropic domestic company Valenta Pharmaceuticals.

Advantages and disadvantages

Perhaps the advantages of nootropic tablets should include it the disadvantage is a short-term invigorating effect, but this effect is like once became the reason that Phenotropil is banned by anti-doping the committee. In domestic practice, this nootropic is used relatively broadly, but in the developed countries of Europe and in the USA it unknown and not used. Recommendations for its use in the official world health organization (who) is not there is, as well as a serious evidence base.

Encephabol

Popularity Rating: 4.8

Encephabol

Encephabol, or pyritinol, is a kind of nootropic a medicine that contains a derivative of vitamin B6. As known, Vitamin B6 itself, or pyridoxine, which comes in the form of hydrochloride, together with thiamine, or vitamin B1, and cyanocobalamin, or vitamin B12 make up the group of neurotropic vitamins, and are widely used in clinical practice. Encephabol shown, according to the manufacturer, with various forms of dementia, mental retardation, impaired memory, attention and orientation, with the consequences of traumatic brain injury.

Nootropic medicine is available in 100 mg tablets and in the form of suspension for oral administration. Adults need 2 tablets. or 2 teaspoons three times a day, and newborns can prescribe from 3 days after birth, 1 ml per day. According to the statement manufacturer, therapeutic success is achieved after a month, and optimal effect after 3 months. Produces this nootropic Austrian company Merck, and this drug costs about 800 rubles. behind one pack of suspension in 200 ml.

Advantages and disadvantages

The negative aspects of Encephabol include the absence of evidence base for each of the stated testimonies, or at least serious study on one of them with a high level reliability, and, perhaps, individual intolerance. TO the positive side of the nootropic is a rare development of this intolerance.

Glycine

Popularity Rating: 4.7

Glycine

Glycine is truly popularly loved and cheap. drug. It is used under the tongue or absorbed before bedtime, it prescribed for children and adults to improve memory, performance, it is prescribed in large quantities to patients after a stroke. FROM biochemistry point of view, glycine, or glycol, is the simplest amino acid found in almost any protein, including the composition of many proteins of our body. Also glycine is a neurotransmitter, or carrier of certain signals inside the brain.

This popular love (good demand) pushed so many manufacturers of a combination of glycine in combination with magnesium, with vitamin B6, with vitamin C, and so on. Usually these pills taken to relieve stress, facilitate falling asleep, and they are taken sublingually for resorption, in tablets or in the form of powder after the tablet is ground. It is shown to adults by one or two tablets immediately before falling asleep, and with others disorders of the nervous system, the instruction prescribes a certain dosage regimen. The cheapest domestic glycine can be bought, starting from 19 rub. for 50 tablets.

Advantages and disadvantages

The drawback of all nootropics is one, but extremely important: no evidence that they are effective. Yes, glycine is neurotransmitter. But the fact is that the neurotransmitter to regulate subtle relationships in the central nervous system, should it is produced as acetylcholine, norepinephrine, serotonin. There will be no benefit if the pick in large quantities is come from the intestines with food to the brain in quantities of hundreds times the desired concentration, or absorbed into the sublingual vessels. There is a blood-brain barrier that prohibits carry to the “holy of holies” of the body, its command cutting and the control apparatus is everything that has been absorbed from the stomach indiscriminately. That is why glycine, which is administered through the mouth, practically does not enters the central nervous system and as a mediator there works, and there is no modern evidence-based research on it. In other words, biological effects and chemical (in vitro) from there is glycine, but therapeutic ones are invisible and not proven.

The positive, and certainly worthy effect of these pills are sometimes a quick onset of calm, physiological sleep in those impressionable subjects who are holy believe in the healing power of glycine. Therefore, glycine may well be a kind of inexpensive and effective placebo, or dummy, all the power which is based on the faith of the patient.

Semax

Popularity Rating: 4.7

Semax

Semax is not just one amino acid, but as many as 7 amino acid residues synthesized in one short chain. A medicine is produced in the form of drops in the nose, at a concentration of 0, 1, or 1%. This synthetic protein sequence repeats one of fragments of adrenocorticotropic hormone, but devoid of hormonal activity. According to the manufacturer, this drug also has nootropic, antioxidant, and cerebroprotective action, and due to the original mechanism of absorption may be used in ophthalmology, and after 4 minutes the agent penetrates the structures of the central nervous system, and therapeutic effect even with a single administration continues day. Manufacturers have established various dosage regimens. So, with damage to the optic nerve, instill three drops in each nasal passage three times a day, and for the prevention of stress – one drop in each nasal passage twice a day.

Manufacturers recommend using drops throughout the spectrum. cognitive impairment, the effects of stroke, encephalopathy, for prevention of mental fatigue, strengthening adaptive of opportunities. Contraindications include individual intolerance, pregnancy and lactation, psychoses and convulsions, and also age up to 5 years. This nootropic drug is produced domestic CJSC Peptogen, and is not cheap – at a dosage of 0.1% of 350 rubles .; and in a dosage of 1% – for 3 ml will have to give already 1750 rub.

Advantages and disadvantages

The disadvantage of Semax is the lack of a clear mechanism action common to all nootropics randomized clinical studies, and its complete unknown in countries Western Europe and the USA, and silence about Semax Worldwide Health Organization (WHO). Against this background, enough doubtful is the price of almost 2000 rubles. for a large dosage, but somewhat calming is the fact that Semax practically there are no symptoms of overdose and drug interactions, and he is unlikely to harm.

Cerebrolysin

Popularity Rating: 4.7

Cerebrolysin

Nootropic cerebrolysin is a biological drug, that is, a whole complex of protein-like peptides that get from the brain of pigs. In general, the belief that nootropic animal brain preparations help the brain man, is an analogue of ancient beliefs that eaten a strong adversary will make you equally strong. IN domestic practice Cerebrolysin is also prescribed for various types of cerebrovascular accident, with consequences stroke, with mental retardation, dementia, with the consequences traumatic brain injuries.

Cerebrolysin in ampoules is produced, the most popular dosage of 5 ml, in one package five ampoules. Produces Cerebrolysin in some cases, foreign companies, but by order Russian manufacturer and for the domestic market. Cost one package of cerebrolysin starts from 915 rubles.

A little about the issue price: the manufacturer recommends the best a course of administration of a nootropic drug in the form of daily injections or infusion, and the duration of the course is usually an average of 2 weeks. In this case, single doses that are recommended, with intramuscular injection should not exceed 5 ml, with intravenous the introduction of a bolus, that is, immediately – 10 ml, and by setting intravenous infusion slowly drip up to 50 ml per day, for example with a stroke, and with the consequences of brain injuries. So way, to the patient daily, even after a mild concussion no one forbids the brain to drip the drug for 1800 rubles. if take the maximum daily dose (at the price of one ampoule in 5 ml at least 180 rubles.). Thus, for a course of treatment for two weeks of daily droppers, you can pay 27,000 rubles.

Advantages and disadvantages

As usual, high-quality clinical studies with high level of evidence accepted drugs in action in western countries at There is no cerebrolysin. However, he is everywhere in our country assigned and successfully advertised. Generally, all biological drugs derived from other creatures that are introduced, including number and intravenously, in developed countries or generally prohibited to imported into the country or expressly prohibited for use, since can carry prion infections. But even without it, in 2010 Cerebrolysin has been shown to be ineffective even at high doses. for the treatment of stroke. Is the purpose of this nootropic the drug is literally beneficial to the prescribing physician, in This case remains open. But with confidence you can argue that in our country such cases are not a rarity.

Cortexin

Popularity Rating: 4.6

Cortexin

There is nothing special to say about Cortexin, except for pork hoods. a cerebral horn fraction was added to cerebrolysin cattle, and expanded indications for children (up to 20 kg of weight, that is, almost from birth). Manufacturer endows this nootropic drug with the ability to improve brain function, protect neurons from damage, increase their survival and resistance to stress, activate their function, and many others useful properties. Cortexin recommended for use in complex therapy, that is, together with any by other means. The manufacturer, apparently, has no reason trust your nootropic drug, since in monotherapy, then if there is only one applied, there is a big risk that there may be no effect, and it will be immediately visible.

This nootropic is contraindicated only in case of individual intolerance, as well as during pregnancy and lactation. Manufacturer cites lack of clinical data research for pregnant and lactating. But, apparently, they are not needed: Cortexin is already in demand.

Cortexin manufacturer is a domestic company Geropharm, and the minimum dosage of 5 mg per bottle will cost you 540 rub for 10 bottles. In this case, a single dose, for example, with stroke, is 2 bottles 2 times a day for 10 days, or 4 packs.

Advantages and disadvantages

The biggest disadvantage of this nootrop is reluctance drug manufacturers subject it to pharmacokinetic research, which is routine, but it turns out the manufacturer knows how this drug works – it’s significant dignity. Here are two quotes from the official instructions: “the composition of the drug does not allow for the usual pharmacokinetic analysis of individual components. “And second quote:” Mechanism of action Cortexin® is due to activation of neuronal peptides and brain neurotrophic factors; metabolic balance optimization excitatory and inhibitory amino acids, dopamine, serotonin; GABA-ergic effect … .. “. Question: if the manufacturer does not can determine which components are in the nootropic drug, how could they conclude about his beautiful effectiveness? And as the rest of the world is not yet ready to apply it a miracle in practice?

Mexidol (Mexiprim)

Popularity Rating: 4.6

Mexidol

This nootropic drug contains ethyl methyl hydroxypyridine. succinate, that is, the only chemical substance that belongs to the group of antioxidants. Like the other nootropics, this drug is indicated for use in overload and mental overstrain, with anxiety and cognitive impairment, with neurosis, in chronic alcoholism and toxic encephalopathy, with damage to the vessels of the brain, including in the elderly, and also with traumatic brain injury and its consequences.

Each Mexidol tablet contains 125 mg of active substances, and it should be used 1 to 2 tablets three times a day, maximum can be used no more than 6 tablets, and the course of treatment is an average of 3-4 weeks. In case of relief of alcohol withdrawal syndrome is quite enough 7 days. Produces Mexidol domestic company ZiO-health, and one package in 50 pills will cost 360 rubles.

Advantages and disadvantages

The disadvantage is the same, namely, no serious data with evidence-based medicine positions. This, of course, does not mean at all that there were no studies at all. Of course they were, but patients always there were few, research errors were many, no randomization and blindness. Blinding is a prerequisite research objectivity: blind research is when the patient doesn’t know if he is given a test medicine or a placebo, a “dummy” for comparison. Double blind is when even the doctor doesn’t know he prescribes a dummy or the drug declared in the study. Any proper research costs money, including patient insurance, and as a result, the validity and value of these studies on Mexidol is very doubtful. For other data, nootropic drug may affect ability to drive vehicles, and during the treatment period it is better to abandon driving vehicles, and with an overdose or at maximum dose may develop drowsiness.

Cytoflavin

Popularity Rating: 4.5

Cytoflavin

Cytoflavin is a complex nootropic drug, which contains inosine, vitamins – nicotinamide and riboflavin, and succinic acid. Pharmacological it refers to combination of metabolic drugs, and is indicated for the consequences stroke, with atherosclerosis, neurasthenia, cerebrovascular pathology. At the same time, succinic acid helps to optimize cell energy metabolism, nicotinamide and riboflavin are necessary for cellular respiration and stimulation of ATP synthesis, and inosine is a precursor to a high-energy compound – ATP, which is a donor of intracellular energy.

Take a nootropic drug should be 2 tablets twice a day morning and evening, but no later than six in the evening, duration course – 25 days. No cases of overdose have been established, side effects may manifest as a headache, or slight discomfort in the abdomen, as well as in the form of allergic reactions. The drug is contraindicated in pregnant and lactating mothers in connection with insufficient research. Produces domestic cytoflavin Polisan company, and a package of 50 tablets will cost 360 rubles.

Advantages and disadvantages

Of the disadvantages of a nootropic drug, it should be noted that according to in essence, it is not a nootropic, since it is a combined a remedy from vitamins and energy metabolites. Cytoflavin is a fairly well-tolerated drug, like in others he also has no nootropics, reliable evidence base, but subjectively, many patients, especially the elderly, note improvement after parenteral administration of cytoflavin. Does it apply is it to the effect of auto-suggestion, or does it really help nootropic drug – is still unknown.

Pantogam

Popularity Rating: 4.5

Pantogam

Pantogam, or hopantenic acid, internationally classifications relate to psychostimulants, and to nootropic drugs. Apply it, according to the manufacturer, should be very many indications, except for standard mental and neurological diagnoses, in this acid even in indications there are “activity limitations caused by the decline disability. “Such an overly broad interpretation of indications for application (and, of course, in favor of the product) cannot but cause surprise.

Each tablet contains 250 mg of calcium hopantenate, and is taken recommended for adults no more than 3 g, or 6 tablets per day, for children also no more than 3G per day. In some cases, the duration of the course treatment can be 6 months, and after a break of 6 months repeated such a course is possible. We will not list in this review all the detailed dosages of Pantogam, let’s just say that apart from 250 and 500 mg tablets, the drug is available in syrup, which contains 100 mg of active substance per 1 ml. Produces it medicine domestic company Peak Pharma. Buy a bottle syrup weighing 100 milligrams can be for 340 rubles., and a package of tablets maximum dosages of 0.5 g in the amount of 50 pieces for 470 rubles.

Advantages and disadvantages

As mentioned above, the disadvantage of all nootropics is how minimum lack of evidence base, which is why they are not are applied in developed countries of Europe, in Israel and in the USA. But u Pantogam’s nootropic drug situation is much worse. This drug banned in Japan in the early 1990s, as it was it was proven that it was the intake of hopantenic acid that led to a number of fatal complications that occurred with the so-called Reye’s syndrome (encephalopathy and liver damage in children and adolescents, usually after the appointment of acetylsalicylic acid). In order not to be unfounded, we provide links to scientific papers (https://www.ncbi.nlm.nih.gov/pubmed/2063999 https://www.ncbi.nlm.nih.gov/pubmed/3826551 https://www.ncbi.nlm.nih.gov/pubmed/3379435).

Conclusion, or the happy fate of nootropics in Russia

nootropic drugs

A whole series of pills could be given, and in detail to list in the ranking such drugs as Picamilon, Phenibut, Fezam, Gliatilin, Aminalon, Cavinton, Ceraxon, which positioned as a means with nootropic action. But that we we won’t do it, because we’ll start repeating ourselves.

So, Picamilon also in the United States of America was not only recognized as a faked nootropic drug, but even excluded from the list of dietary supplements. Researchers from the FDA just analyzed tablets in which the active substance was in different numbers, but in one of the tablets it was not at all detected. Such falsifications are very strictly punishable by law for abroad, but what is the composition of the tablets in the Russian Federation, and what machines are used in pharmaceutical plants to ensure uniform content of active substance in each tablet, this information we do not know, and do not even think about it.

This is information that allows the reader to think about it at all. is not a “fly in the ointment”. No coincidence list nootropics are not entitled “best” drugs, but “popular” drugs. And that is a big difference. If there is a better nootropic drug, then this means that there is the worst, that is, from one there is a cure, but the least effect is the least. prove according to the laws of mathematics and medical statistics, because the measure is efficiency.

As for the nootropic drugs, it is they who have extremely a large list of testimonies, which sometimes take dozens diagnoses. Truly, you can catch a lot of fish in muddy water. If a we compare it with serious drugs, for example, to reduce cholesterol or lowering blood pressure you’ll see which is enough for one or two indications for use, for example, hypertension and heart failure. As it was shown in the review, manufacturers attract even such diagnoses that are not indicators of an organism’s disease, for example, “violation of adaptation when changing lifestyle”.

Countries that are world leaders are trying get rid of those drugs whose effect cannot be proved as well as from dishonestly acquired and “laundered” money. Secured wealthy Russians go to Germany, Switzerland, Israel and USA. And none of them thinks anxiously that they will not be there prescribe cortexin, cerebrolysin, or picamilon. In the United The states of America, for example, do not have a single approved by international drug recommendations to improve intellectually mnemonic or cognitive functions, both in patients and in healthy people. In developed countries, nootropic drugs in general never registered as medicines because they are not tested with evidence-based effectiveness.

Of course, it is best to give the nootropic drug to the patient, as a magical tool to stimulate the brain than to tell him boring and boring advice on how to have a healthy lifestyle, normalization of weight, quitting smoking and alcohol, healthy sleep, and sports will make him healthy. People perfectly understand and feel that such non-drug methods are effective, and, most importantly proven in numerous international research, not only for prevention, but also for the treatment of many neurological diseases. But man is designed so that he wants all at once, with a minimum expenditure of their strength. Therefore before listen to the advice of a domestic specialist and run buy Cortexin, Piracetam or Phenibut, think several times, Is it necessary for your health. Remember that a wealthy Englishman or an American will never do this, but a German doctor or a specialist from the USA, where the medical profession is prestigious and highly paid, will never prescribe nootropics to the patient, because they are clinically ineffective.

Popularity rating based on analysis of service demand data wordstat.yandex.ru.


Attention! This rating is subjective, not advertising and does not serve as a guide to the purchase. Before the purchase consultation with a specialist is necessary.

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