The 9 Best Medicines for Teak (Tic hyperkinesis)

Review of the best according to the editors. About the selection criteria. The the material is subjective, is not advertising and is not serves as a guide to the purchase. Before purchase is needed consultation with a specialist.

Before prescribing any treatment to a patient who has there are tics, he needs to be examined not only by a therapist, not only with a neurologist – but also with a specialist center extrapyramidal diseases. Such centers are in every major city, since tics belong to extrapyramidal hyperkinesis. To distinguish real ticks from imaginary ones, for example, hysterical ones, sometimes lengthy examinations of the patient are necessary. First of all, the tick should be a really involuntary movement that unnecessary and redundant. Tick ​​should be due to defeat extrapyramidal nervous system, which manages the unconscious movements.

About unconscious movements

Many people without medical and biological education do not they understand correctly what an unconscious movement is. Some even say that this movement is impossible, because when a person lies unconscious, then he “does not move.” In fact, everything not this way. Together with those movements that are subject to our will, there is a parallel nervous system about which we do not suspect. It is called extrapyramidal, because it lies outside control the pyramidal path through which all pass the movements we control.

The extrapyramidal system “manages” the same muscles, – arms, legs, torso. But she does it quickly, and intercepts if necessary, muscle control in consciousness, in the cerebral cortex brain. Here is a simple example that everyone knows. You slipped on ice, but did not fall. You suddenly and sharply waved your hands, they bent, “danced” for a couple of seconds and restored their balance. Everything happened unexpectedly: you yourself cannot remember and to reproduce the sequence of movements that came out of you completely unconsciously, but restored the position of the center gravity.

Here is an example of the extrapyramidal system, which allows critical situation restore balance. But sometimes she goes out out of control, and here the tics, or tic hyperkinesis, are one example of disorders of this system. Common name of these hyperkinesis – dyskinesia, and the tick among them is far from the only state. Together with them we can name: tremor, athetosis, chorea, myoclonus, and other rare disorders that studied by neurologists – extrapyramidal specialists diseases.

Each hyperkinesis has its own motor “pattern”, and it’s hard to confuse with any other. For example, tremor, which It’s known to everyone – it’s a fine trembling of the neck, head, fingers. Parkinsonism tremors are rhythmic movements in the bases of the thumbs, similar to the “coin count”. Athetosis which occurs quite rarely as a complication of encephalitis – this slow, elaborate and worm-like movement of small muscles, for example, fingers of hands. What is tic or tic hyperkinesis?

What are ticks?

A tick is a single movement or group of movements that are conducted jerky ones that have no rhythm and they involve separate muscles or muscle groups in this activity. Implemented during ticks and other, normal muscle activity. Therefore a tick may occur a walking, writing, talking person. Tic hyperkinesis as if “for a time” is imposed, and then – leaves the person.

In some cases, a tick can also remind purposeful movement, and the patient can even fight them, and very successfully. By force of will, he can for a few seconds, or even for a minute suppress this violent movement but then gradually the inner struggle grows and the teak breaks out again. Sometimes patients describe that they really want to do these movement, this need is simply irresistible.

In each patient, tics are repeated at special intervals, and each patient’s “tick repertoire” is his own, individual. It is extremely important that during sleep tics do not disappear, but continue to appear in their own rhythm. What are tic hyperkinesis? Their classification is very complicated, and we won’t stop at it, let it be done specialists.

We can only say that ticks are simple and complex. Simple tics define any one kind of movement, sensation or exclamation (vocal tics). So, a motor, simple tick is a squeeze eye shrug. A complex motor tick is a repetition seen gesture, punching himself in the chest, that is, committing movements that already require the work of several groups coordinated muscles. So, the same simple muscle tick can be sudden or very fast, then it’s called classic. Their fast ticks are often resolved quickly, and with them fighting with a strong-willed effort is much easier. And here is a slow tick called dystonic, almost uncontrolled the patient. This, for example, persistent squinting eyes, or blepharospasm.

There are sound, or vocal tics. This is a snort coughing and whistling, grunting, and even irresistible the need to pronounce obscene or other people’s words (coprolalia or echolalia). There is also a touch tick with a pronounced sensitive component. The patient begins to experience unpleasant and alien a sensation that simply requires some kind of movement.

About the causes of tic hyperkinesis

Why do tics come about? Quite often they occur primarily, that is, out of touch with any disease, and most often start in childhood or in adolescents. Sometimes such ticks then pass without a trace, and this can be considered an option for maturing bonds between different parts of the central nervous system: frontal bark, basal extrapyramidal ganglia and limbic system. With this boy, they suffer twice as often as tics than girls. One of the most famous diseases associated with various hyperkinesis and tics, is Tourette’s syndrome (de la Tourette), in which there is a combination of motor, that is, motor, and voice, i.e. vocal ticks that may occur in different time.

It is believed that the manifestation of Tourette’s syndrome may be associated with genetic defect. Ticks change in dynamics, in youthful and at a younger age they are already weaker compared to adolescents. And in adulthood, tics very often stop and without any treatment. If they do not disappear, then they are significantly reduced. Not only their intensity decreases, but also the patient and gets used to them, therefore, ongoing ticks to a lesser extent worsen quality of life than fresh ones that have just begun. However, one third of patients continue to have tics throughout life, but they lead to permanent disability extremely rarely: people adapt well to obsessive movements. Stressful the situation always provokes an increase in ticks, and this determines one of the types of treatment – the appointment of antidepressants.

Doctors noted that in patients with common tic hyperkinesis, and especially with Tourette’s syndrome, exist and psychical deviations. This is obsessive-compulsive syndrome, or obsessive conditions, attention deficit disorder in the presence of hyperactivity, and other disorders. Therefore, such patients psychiatric drugs are also prescribed, for example, antipsychotics, and especially in severe cases. If talk not about primary, but secondary ticks, then their cause may be various diseases and injuries. This is postnatal injury. central nervous system, medication, for example, psychostimulants, anticonvulsants, or antipsychotics. Quite often extrapyramidal hyperkinesis in general and to ticks in in particular, encephalitis and vascular pathology of the head brain, acute and chronic poisoning.

Drug therapy

All of the above confirms the great ambiguity of the problem. ticks. Sometimes they don’t need to be treated with drugs at all, simply eliminating overwork, and in adults – stop smoking and drink strong coffee. Although cases are not uncommon now when teenagers not only smoke and abuse coffee, but also have heavy addictions – from chemical salt addiction to alcoholism.

If treatment for tics is still necessary, then the treatment program should be long. And when a specialist undertakes to treat such the patient, then he can never tell in advance when the patient get rid of his disease. In any case, the treatment of ticks does not may be shorter than 3-4 months, and sometimes it lasts somewhat years old. Moderate tics treated with benzodiazepines, in Russia drugs that alter the metabolism of gamma-aminobutyric are used acids. Moderately expressed tic hyperkinesis require prescriptions of mild antipsychotics, or even atypical drugs from of this group.

Consider the most effective drugs that are prescribed doctors with various types of hyperkinesis. Many of these tools You can not buy in a pharmacy without a prescription, for example, antipsychotics or anticonvulsants. Every drug first represented by its INN, or international non-proprietary the name. Then, if any, the name of the original funds, and then its generics, or copies. Price is also given. (or range) for one package, which is valid for all pharmacies of all forms of ownership in the territory of the Russian Federation for fall 2019.

The list of drugs does not in any way reflect rating, importance or popularity. Their sequence presented in random order. And start the review with the drugs, which are used in the most mild cases and often lead to to success. These are drugs from the group of GABAergic drugs.

The best medicines for tic (tic hyperkinesis)

Nomination a place Name of product price
GABA-ergic preparations 1 Hopantenic acid (Pantogam, Gopantam) 456 rub
2 Aminophenylbutyric acid (Noofen, Anvifen, Phenibut) 1 150 rub.
Anticonvulsants 1 Clonazepam 148 rub
2 Topiramat (Topamax, Maxitopyr, Topalepsin, Toreal) 772 rub
3 Levetiracetam (Keppra, Levitinol, Epiterra) 316 rub
4 Valproic acid (Depakine Chrono, Convulex, Convulsofin) 214 rub
Antipsychotics 1 Haloperidol 28 rub
2 Risperidone (Rispolept, Risset, Torendo, Speridan) 244 rub
3 Tiapridal (Tiapridal) 1 309 rub.

GABA-ergic preparations

These drugs are mild, and especially they are indicated in the stage debut of tic hyperkinesis in preschool and primary school age. The drugs act on the same ion channels as gamma-aminobutyric acid, which is a inhibitory mediator in the central nervous system. The purpose of these drugs leads to enhance intellectual functions, increases motivation, reduces symptom of asthenia and irritability. In children, these funds used to correct delicate and non-rough ticks, as well as stuttering. However, for rubles, these funds are not used in connection with lack of evidence. Therefore, it is possible that a positive effect is associated with the optimization of the regime, rest, improving the quality of sleep in a teenager. In the event that in the debut tic disorder could not cope with the appointment preparations, then in a month or two it is necessary to revise the tactics treatment, and if necessary, select medicine from other groups anticonvulsants or antipsychotics, but necessary after consulting a psychiatrist and extrapyramidal specialist disorders.

Hopantenic acid (Pantogam, Gopantam)

Popularity Rating: 4.9

Hopantenic acid (Pantogam, Gopantam)

Pantogam and its analogues are very fond of appointing domestic children’s neurologists and psychiatrists. But the broad purpose is not talking about that the drug is “best.” The volume of readings is impressive: from physical overload and impaired copper metabolism to mental backwardness, stuttering, tics, epilepsy and cerebral palsy. List of indications can go on and on. They are treated with the effects of intracranial trauma, excessive activity and urinary incontinence, neurotic disorders and attention disorders. Pantogam is treated and various tics in children and adolescents, it can also be used in adults.

The drug is available both in tablet form and in the form of syrup. One pack of 50-mg tablets of Pantogam will cost from 550 to 870 rubles. The cost of the syrup is about the same, the packaging from 100 ml of syrup will cost from 330 to 600 rubles .. A single dose for children usually is either one tablet, or up to 5 ml of syrup. The daily adult dose for children should not exceed 30 ml, i.e. 6 tablets, or 3 grams of the drug. The dose for adults is the same course duration – from 1 to 6 months.

Advantages and disadvantages

Pantogam has one big minus that can outweigh all the advantages: this is the lack of evidence, and the rejection of it Applications in Western countries and in Japan. In the last Pantogam banned since 1990. After taking it, a number fatal complications, or a sharp deterioration in the condition of patients with rett syndrome. In the world medical literature, only only a small amount of controversial work on Pantogam’s effectiveness. The World Health Organization does not recommend it (he unknown), in the USA it is unknown. Accordingly, does not exist and the proven effectiveness of this drug and its analogues in tics. Therefore, if the doctor prescribes this remedy, then it is desirable talk with your doctor and find out the reason for the recommendations.

Aminophenylbutyric acid (Noofen, Anvifen, Phenibut)

Popularity Rating: 4.8

Aminophenylbutyric acid (Noofen, Anvifen, Phenibut)

Noofen and its analogues are classified as psychostimulants and nootropic drugs. In addition to ticose hyperkinesis, our doctors prescribe it with abundant emotional disorders, anxiety and withdrawal symptoms, enuresis and neurosis, stuttering and sleep disturbances. Some experts prescribe it for Meniere’s disease, dizziness, and other disorders of the vestibular apparatus. Sometimes the remedy even used as a medicine for motion sickness and motion sickness. Composed Noofen from aminophenylbutyric acid hydrochloride, and has calming, and at the same time stimulating effect.

The medicine is administered orally after meals, for adults 1-2 tablets three times per day. The dosage for children is determined by the pediatrician, usually by one tablet three times a day, and not more. Launches Noofen Latvian company Olainfarm. He is the most expensive drug. on the market for all aminophenylbutyric acid products. Cost of one packaging Noofen, from 20 tablets, ranges from 900 to 1400 rubles. Domestic drug Anvifen has a cost of 300 to 500 rubles., And the cheapest analogue is domestic Phenibut. It can be purchased at a price even less than 100 rubles .. for the same packaging.

Advantages and disadvantages

With Phenibut (Noofen) the same international situation as with hopantenic acid. We use this tool extremely widely, not only for treating ticks, but for stopping anxiety, for the treatment of insomnia, dizziness. Some kind of effect from him, certainly there is, since there is evidence that in Europe on him “sit down” as a drug. However no randomized clinical trials performed on all the rules were not implemented, and in no international recommendations he does not meet. In Cochrane reviews and protocols evidence-based medicine is not, American Federal Agency (FDA) has no data on this drug, World Organization health in its recommendations anywhere this drug for no treatment for tics.

Anticonvulsants

Anticonvulsant drugs, or anticonvulsants are the second stage of treatment for tic hyperkinesis, and if talk about international practice, then the first step, because GABA-acting drugs are used only in The Russian Federation and the countries of the former CIS, the evidence base in they are not. Therefore, if the patient has non-drug methods of dealing with tics and other hyperkinesis were unsuccessful, then he prescribe anticonvulsants, or anticonvulsants. Below some of them are given.

Clonazepam

Popularity Rating: 4.9

Clonazepam

Clonazepam has virtually no anticonvulsant commercial copy names, and it is inexpensive: from 90 to 120 rub. for 2 mg tablets in an amount of 30 pieces. The drug in pharmacies happens infrequently, and is sold only by prescription. The drug is a benzodiazepine derivative, also has sleeping pills and central muscle relaxant effect also slightly affects GABA mediator, slowing down the transmission of nerve impulses. All this allows him to reduce emotional stress, ease anxiety and fear, cause sedation and an anticonvulsant effect. All this suppresses spontaneous activity that occurs with ticks. Naturally, most often the drug is used for epilepsy, but It is also prescribed for tic hyperkinesis. In addition, from rare evidence can be called somnambulism, insomnia, psychomotor agitation.

As for the dosage regimen of this drug, for adults the initial dose should not exceed 1.5 mg per day, moreover, being divided into three doses. For the treatment of ticks with clonazepam there are special schemes, so we are here for exact dosages We will not give.

Advantages and disadvantages

Clonazepam has a number of serious contraindications. First of all, it’s severe respiratory failure, severe depressive states. By the way, the latter is not uncommon in patients with severe tics, but clonazepam in such patients may increase suicidal tendency. Also Clonazepam should not be taken in pregnant and lactating women, and there is a number of conditions when it should be taken with caution. So, it is not recommended to take against a background of acute bronchitis and pneumonia, because it suppresses the cough reflex and is able to deepen infectious lesion of the bronchopulmonary system.

Topiramat (Topamax, Maxitopyr, Topalepsin, Toreal)

Popularity Rating: 4.8

Topiramat (Topamax, Maxitopyr, Topalepsin, Toreal)

Topamax is a modern antiepileptic drug, manufactured by Janssen cilag and capsules in an amount 60 pieces of 25 mg can be bought in pharmacies from 600 to 1700 rubles .. This the drug is used as monotherapy in patients with ticose hyperkinesis, and is prescribed in certain dosages, which may not be so big. So, the minimum effective dose the drug in various forms in patients with epilepsy is 200 mg per day, but the initial dosage may be even less. it one 25 mg tablet at bedtime for a week. If there is an effect, you can stop at such a small dose. But anyway the maximum daily dose should not exceed 500 mg, i.e. 20 pills. This is a very high dose, and it is used in patients with epilepsy, and people with teak have special schemes Destination Topamax. This medicine is also used for prevention of migraine attacks.

Advantages and disadvantages

Topiramate is well tolerated, has a small amount of side effects. effects. Of these, the most common decrease in concentration attention, drowsiness, decreased appetite, emotional lability and weight loss. However, these effects are dose dependent, and more often all occur in patients with severe forms of epilepsy when topiramate is prescribed in fairly high dosages. At extrapyramidal hyperkinesis doses are not so large, so its the application is pretty safe.

Levetiracetam (Keppra, Levitinol, Epiterra)

Popularity Rating: 4.7

Levetiracetam (Keppra, Levitinol, Epiterra)

Many anticonvulsant drugs in there are no specific indications or dosages in the official instructions, relatively tic hyperkinesis. So, the official instruction to levetiracetam, or Keppra indicates six different indications for use, but all these are some form of epilepsy. IN in the case of extrapyramidal pathology, doctors prescribe any funds will be recognized “through their channels”: symposia, materials of congresses, presentations from special magazines. And in a few years it the indication is officially entered into the instructions for use.

Levetiracetam is a highly soluble drug, and with it intravenous administration and administration in tablets, the doses have the same equivalence. But with ticks, the doctor prescribes almost always only pills. The drug is used for extrapyramidal pathology in dosage of 500 mg per day, which is divided into two doses, if it’s about monotherapy. However, to take the minimum effective dose of the drug, you must use instructions of a neurologist extrapyramidal disorders.

Produces Keppra Belgian company USB-Pharma. One pack of 30 tablets, calculated per month of use, will cost in October 2019 from 1300 to 1800 rubles .. Perhaps the cheapest domestic levetiracetam half the dosage, i.e. 250 mg No. 30 can be purchased at a price of 310 rubles .. for packaging, in the pharmacy drug ordering service. It will be an INN generic levitracetam production of the domestic company Ozone LLC.

Advantages and disadvantages

Keppra is a highly effective drug, but, like any another modern antiepileptic drug it has serious contraindications. It can not be used in children under four years, as well as in old age, it is not recommended to take it with chronic progressive renal failure. If goes it is about the appointment of levetiracetam in pregnant and lactating women, then the drug in some cases can be used, but only under a special medical supervision, and if the benefits of the application the drug will exceed the potential harm of the drug funds for the development of the child.

However, tics with all their deterioration in the quality of life of patients do not are life threatening conditions, and a pregnant woman with the presence of ticks can be transferred to other during pregnancy medications. In addition, pregnancy, in some cases beneficial effect, leads to significant improvement the course of the disease, and sometimes to complete recovery, since the etiology and pathogenesis of tic hyperkinesis is not yet completely studied.

When applying, it should be remembered that Keppra causes the following side effects: headache, nasopharyngitis, drowsiness, dizziness and fatigue. Of course, there are rarely others symptoms such as eosinophilia, depression, double vision, and dizziness, therefore treatment with levetiracetam should always carried out under the supervision of a physician. And the last one. Not to be confused anticonvulsant drug Levitracetam with Levitra (vardenophil) – a drug for the treatment of erectile dysfunction in men.

Valproic acid (Depakine Chrono, Convulex, Convulsofin)

Popularity Rating: 4.6

VALPROJEIC ACID (DEPAKIN CHRONO, CONVULEX, CONVULSOFIN)

Depakine chrono, like other valproates, penetrates well the brain and cerebrospinal fluid, where 10% of concentration in blood serum. The drug is used for complex therapy for many tic hyperkinesis, and quite severe convulsive epileptic seizures, including in children. It is indicated for the treatment of adults and children over 6 years old, and in the treatment tics, it can be prescribed both in the form of monotherapy, and together with other drugs. In addition to anticonvulsant effect, Depakine has a sedative and central muscle relaxant relaxing striated the muscles.

It must be used in dosages indicated by the attending physician, but first, an initial dosage of 5 to 10 mg per kilogram of body weight. After a week, it is increased by 5 mg, until satisfactory effect. Moreover, for adult patients, with body weight from 60 kg and above, the average daily dose with prolonged treatment is 20 mg per kilogram, that is, from one and a half to 2 g per day. Produces Depakin Chrono French company Sanofi, and a pack of 30 tablets of 500 mg will cost between 200 and 650 rubles.

Advantages and disadvantages

Valproate, despite its clear clinical efficacy, have a fairly large list of contraindications and an impressive list of side effects. If you do not take the standard high sensitivity to the drug, then the main contraindications to chronic and acute hepatitis, severe liver disease, poor tolerance of valproate in relatives relatives of patients, acute chronic pancreatitis, some hereditary mitochondrial diseases, hereditary changes in urea synthesis, pregnancy, children under 6 years old.

Depakine chrono should be given very carefully with tic hyperkinesis in combination therapy, with another anticonvulsant, it is better to implement another method treatment. The risk of liver damage is significantly increased. The drug can cause side effects such as anemia, decrease in platelet concentration, can even provoke tremor and the appearance of extrapyramidal disorders, and in which case it application should be discontinued. Chrono may develop on Depakin reversible, and even irreversible deafness, pleural effusion appears and other, rather severe side effects.

Antipsychotics

Drugs from the group of antipsychotics are often used in severe cases of various common types of complex ticks, when non-drug methods and drugs from other groups help badly. The most commonly used haloperidol, which can help 70% of patients, and achieve either remission or a clear decrease in frequency and duration of attacks. Drugs such as fluorphenazine and pimozide also used in complex therapy, but unlike haloperidol they are better tolerated because they have incomparably less sedation, and this is especially important when long term treatment. Their minus – they are very rarely in pharmacies, and we will not describe them here. The most common treatment carried out either during an exacerbation of the disease, or for a long time outside depending on the stage of the disease. With sustained dose improvement antipsychotics are gradually reduced, and then they are canceled altogether. Consider the most effective drugs from the group of antipsychotics to reduce the symptoms of tic hyperkinesis.

Haloperidol

Popularity Rating: 4.9

Haloperidol

Haloperidol is one of the “great antipsychotics” that is being treated major and present mental illnesses such as schizophrenia, delirium, various behavioral disorders. But one of the official indications for the appointment of haloperidol is multiple motor tics that are combined with vocal speech stereotypes, then there is Tourette’s syndrome, which occurs in severe form. This drug is butyrophenone derivative, available in tablet form, and in ampoules for injection. It affects dopamine receptors, which are blocked, causing an antipsychotic effect. Acting on the structures of the hypothalamus, it lowers body temperature, lowers gag reflex, and antipsychotic effect is manifested in the fact that the medicine eliminates pronounced personality changes. A drug relieves delirium, manic state, relieves hallucinations, increases the patient’s interest in the environment. Along the way, Haloperidol affects the functions of the autonomic nervous system, eliminates vascular spasm, reduces the motility and tone of the gastrointestinal tract. Haloperidol very well helps with psychoses that accompanied by a pronounced fear of death and anxiety.

It is important to remember that haloperidol is undesirable to take for a long time, because it changes hormone secretion: the anterior pituitary gland begins to excessly synthesize prolactin, and production decreases gonadotropic hormones. This can reduce libido while also cause galactorrhea. Haloperidol is used for tic hyperkinesis in accordance with the combination that is prescribed a doctor. Do not focus on those dosages with which schizophrenia is treated. Haloperidol is always on the list of essential drugs – vital medicines and the drug is worth very, very cheap. So, a pack of 50 tablets of haloperidol will cost from 23 to 50 rubles., the drug is produced in Russia many pharmaceutical companies.

Advantages and disadvantages

It should be remembered that Haloperidol, being taken in high dose, it itself causes and provokes extrapyramidal hyperkinesis in the form of persistent muscle contraction, characteristic symptom of “haloperidol” intoxication of drug addicts is a tonic neck contraction, painful cramp that turns the neck on the side. Therefore, the dosage of this drug, which cannot be bought either in one pharmacy without a special prescription, with Tourette’s disease usually is from 1 to 3 mg. Such a small dosage is also sold in tablets, and is even cheaper: from 36 to 48 rubles. for packing.

Haloperidol is contraindicated in inhibiting central functions nervous system, it can not be used in Parkinson’s disease and epilepsy, as well as with severe depression. The drug is categorically not combined with alcohol, it can not be used in pregnant, lactating mothers. Also, the medicine has a large number of side effects. effects. In addition to these spasms of the neck, on the contrary, may intensify tick-like movements, blood pressure changes. At prolonged use in women, unusual secretion may occur milk, menstrual irregularities, and in men – impotence. Therefore, use haloperidol even for the treatment of severe disorders necessary very, very carefully.

Risperidone (Rispolept, Risset, Torendo, Speridan)

Popularity Rating: 4.8

Risperidone (Rispolept, Risset, Torendo, Speridan)

Risolept also refers to antipsychotics, which, when activities against hyperkinesis are quite low sedative effect. He, like Haloperidol, is widely used in psychiatry with delusions, hallucinations and schizophrenia, in chronic delusional disorders and obsessive-compulsive episodes. At the same time, the drug also reduces the level of the gag reflex. and lowers body temperature. It is less than classic representative of antipsychotics, chlorpromazine, inhibits motor spontaneous activity, and less often causes side effects. Yes, he, like Haloperidol, can increase prolactin levels and reduce the concentration of gonadotropic hormones in blood plasma with prolonged use. The drug is used to treat severe tics and Tourette syndrome in a dose of 2 to 4 mg per day. Produced it is in tablets of 2 mg No. 20 at a price of 300 to 400 rubles .. In a dosage twice as high, 4 mg, it can be bought at prices from 500 to 1200 rub .., but according to a special recipe. Issues Rispolept as original Janssen cilag, an Italian unit, so you can consider this a Johnson product.

Advantages and disadvantages

Plus of Riperidone – a rather limited amount contraindications, of which in the official instructions only only hypersensitivity. However, restrictions on use quite a lot of drug. These are gross cardiac abnormalities conduction, heart failure, impaired liver function and kidney disease, Parkinson’s disease, the age of 15 years. Given that tics and Tourette’s syndrome is a disease of a young age, then, basically, these restrictions are not very relevant.

However, if we are talking about a lactating woman, then at the time of use risperidone should be discarded. At the drug has side effects. This is insomnia or drowsiness, decreased blood pressure, nausea, and vomiting. In women, it’s amenorrhea, in both sexes – decreased libido. In case of overdose increased sedation, drowsiness, the appearance of heart palpitations, arterial hypotension. IN in case of an overdose, there may just be extrapyramidal disorders while taking risperidone, therefore, it is necessary carefully titrate the dose and use it preferably in short courses.

Tiapridal (Tiapridal)

Popularity Rating: 4.7

TIAPRID

Tiapride is a fairly expensive drug: one pack of 30 100 mg tablets will cost 1,750 rubles, despite the fact that domestic producer – Organika, which produces some of the cheapest drugs. There is also tiapridal, which releases Sanofi-aventis company. Its pack of 20 tablets will cost 1300 rubles .. This drug is not so often prescribed for tics, but it the main application, in addition to ticose hyperkinesis, is various forms of chorea, opium-related behavioral disorders addiction. It is very effective in patients with alcoholic psychosis, withdrawal symptoms and syndrome alcohol addiction.

Tiapridal is used for Tourette’s syndrome and adult chorea in dosage from 300 to 800 mg per day, however, treatment is required dose titration. You need to start with a very low dose, which is only 25 mg per day, and gradually increase it. However, the maximum dosage for severe tic hyperkinesis is not should exceed 300 mg per day. The result is that Tiaprid packaging at an average dosage of 500 mg per day will end after a week, or rather, after 6 days, if the package contains 30 tablets. Accordingly, a monthly course of taking this drug will cost about 6500 rubles, which is expensive in Russia.

Advantages and disadvantages

As with all other cases, antipsychotics are serious medications for treating severe disorders, and tiapride may have side effects and contraindications. Contraindications except hypersensitivity, pregnancy and lactation, and side effects – drowsiness and fatigue, with an overdose may be acute antipsychotic or even malignant antipsychotic syndrome with a rise in temperature to 40 degrees and higher. From the genitourinary system, as in previous cases, antipsychotics, with prolonged use, there may be changes plasma hormones, increased prolactin, galactorrhea, frigidity, gynecomastia and impotence.

Instead of a conclusion

Extremely important in the case of antipsychotics can be called a reception the minimum dose, and its slow rise to acceptable values. It is strictly forbidden to start treatment immediately from high dosages. In the event that the tick is severely leaking, and treatment neuroleptics alone do not bring effect, then apply regimens already with large doses, but still most preferred do not increase the dosage of one drug, but connect to treatment the second antipsychotic, which has a different mechanism of action. For example, risperidone and tiapride, or antipsychotic, are combined with anticonvulsant drug. In the event that there are painful and convulsive cramps if the tick has a painful dystonic character involving the muscles of the neck and face, then it’s possible the use of botulinum toxin. It is aimed in the muscles that take part in tic hyperkinesis.

Of course, the treatment of ticks is not limited to the above. drugs, and even their groups. If a teenager or youth has concomitant hyperactivity disorder and attention deficit then small doses of psychostimulants are prescribed, tricyclic antidepressants. If in addition there is a syndrome of obsessive states, or obsessive-compulsive disorder, then shown SSRI antidepressants, or selective inhibitors serotonin reuptake. They were written about in other articles, therefore, we will not talk about them here. In the treatment of ticks also Gliatilin, nootropic drugs, vitamins are used. Very important apply, first of all, and non-medications. These are the methods psychotherapy, which, although they do not reduce the tics themselves, but change the attitude of patients. This is very important because, in the end Finally, the quality of life improves, the obsessive syndrome decreases conditions and increases social adaptation. It is very important to reduce internal stress by teaching patients relaxation as well the ability to arbitrarily control the tick, using special methods.

Popularity rating based on analysis of demand data service wordstat.yandex.ru.


Attention! This rating is subjective, not advertising and does not serve as a guide to the purchase. Before the purchase consultation with a specialist is necessary.

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