The 11 Best Acne Treatments

Review of the best according to the editors. About the selection criteria. The the material is subjective, is not advertising and is not serves as a guide to the purchase. Before purchase is needed consultation with a specialist.

Acne or acne is a long-known inflammatory disease of the skin appendages. It was probably first described Byzantine court doctors back in the middle of the first millennia of our era. Running cases lead to education cosmetic defect, serve as a source of chronic inflammation skin and scarring. Severe acne is persistent a source of stress, the development of dysmorphophobia, feelings of self inferiority and significantly impairs the quality of life in the extreme cases leading to suicide.

The essence of acne is in the inflammation of the glands that produce skin fat and its output, in the blockage of the excretory duct of the sebaceous glands and concomitant inflammation of the hair follicle. Acne the rash almost never occurs as a single education. If on the skin of the face, shoulders, neck or chest there is no more than 10 acne (without symptoms of inflammation), then such the rash is considered mild. And if more than 40 eels, and almost all of them surrounded by a halo of inflammation with the phenomenon of pain and swelling, merge (conglobates) and proceed with the phenomena of general intoxication, then this serious condition, in which a serious and prolonged treatment.

Dermatologists have many reasons for the appearance of acne, among which the most frequent is hormonal adjustment organism during puberty. To the appearance of inflammatory changes in the sebaceous glands often results in low immunity, pregnancy, poor diet and constipation, use substandard cosmetic preparations.

This review includes drugs that designed for topical application by application on skin, and systemic drugs in the form of tablets. Second a group of drugs can only be prescribed by a doctor, according to indications and in the absence of contraindications. Any self-medication It is dangerous and categorically contraindicated. Not rated traditional medicine will be listed as well numerous physiotherapeutic procedures that are widely used in beauty salons to eliminate the effects of long-term, chronic acne with the formation of scar tissue. These include a variety of masks, peelings, cryotherapy and ozone treatment, darsonvalization, various types of cleansing, phototherapy, dermabrasion and many other means. Them consideration is not the purpose of this rating.

First, those local medicines that are good suitable for treating mild forms of acne, and for this creams, gels and ointments are used. But in the composition of local funds for Acne treatments include antibacterials and antibiotics, therefore, even in this case, before use it is necessary specialist consultation. All prices listed in the ranking, relevant for large cities of the Russian Federation for the beginning of 2019 years, and for pharmacies of all forms of ownership.

Rating of the best drugs for the treatment of acne

Nomination a place Name of product price
The best antibiotics and antiseptics 1 Zinerite (erythromycin + zinc acetate) 628 rub
2 Dalacin gel (clindamycin) 767 rub
3 Klenzit C (clindamycin + adapalene). 562 rub
4 Baziron AC (benzoyl peroxide) 583 rub
5 Skinoren (azelaic acid) 1 100 rub.
The best remedies for reducing inflammation and repair 1 Curiosin – gel 600 rub
2 Delex – Acne, Blackhead Gel 231 rub
3 Bioderma sebium AKN 882 rub
The best drugs of the systemic effect: contraceptives, retinoids, antiandrogens. 1 Jes (Yarina, Jeanine) 995 rub
2 Systemic retinoids (Roaccutane, Aknekutan, Sotret) 1 660 rub.
3 Cyproterone (Androcur) 1 395 rub.

The best means of local action

The purpose of applying local funds is to reduce the allocation sebum, a decrease in the number of bacterial populations located on surface of the skin, and involved in the formation of secondary inflammation, and the fight against follicular hyperkeratosis. Hyperkeratosis leads to delayed removal of dead scales from the skin surface epidermis. Hyperkeratosis provides food for bacteria and pathogenic fungi, the epidermis clogs the ducts of the sebaceous glands, creating plugs. All topical medicines are used in treatment of acne for a long time, they are applied to the affected skin, for excluding eyelids and eye area.

The best antibiotics and antiseptics

First, antibacterial drugs and antibiotics. They greatly inhibit reproduction. bacteria and suppress the very cause of inflammation. However should not abuse antibiotics, as if applied to large areas possible resorption and systemic effects. It is also recommended to regularly change application patterns. antibacterial drugs to avoid the development of resistance microflora to the means used. Recommended for this periodically take detachable from the surface of the foci and conduct bacteriological examination with isolation of pure culture and determination of the sensitivity of microbes to antibiotics.

Zinerite (erythromycin + zinc acetate)

Rating: 4.9

Zinerite

Erythromycin, which is part of Zenerit, is dermatotropic antibiotic. It does not kill microorganisms, but suppresses them reproduction. Acetic zinc salt has an astringent and drying effect, reduces the secretion of sebum and suitable mainly for oily skin. Especially good erythromycin inhibits the reproduction of epidermal streptococci and propionic bacteria, which are most often the main sebum consumers guilty of acne.

Zinerit is produced in the form of a liquid in a bottle with an applicator. Zinerit should be applied to acne twice a day, in the morning and in the evening. By clicking on the applicator, you can dose the amount of fluid. The average daily dose is 1 ml of solution. Average duration the course is 3 months. As a rule, a visible improvement in mild to moderate acne can be noticed already In 2 weeks. Zenerit pharmaceutical company Astellas, the Netherlands, and the average cost of one bottle, which enough for monthly use, is 735 rubles.

Advantages and disadvantages

The advantage of Zinerit can be considered its high safety. Erythromycin can be used even in pregnant women and with breastfeeding, and from local side effects may occasionally a burning sensation and dryness. These symptoms are severe. weakly and soon pass, without requiring withdrawal of the medicine. Big plus there will be a fact that after drying on the skin the solution becomes invisible, and the patient can easily apply Zinerit to the face, it will not be covered with any white spots of zinc ointment, as they think many. The relative disadvantage of the tool is the high price and a small volume of the bottle, but this small disadvantage.

Dalacin gel (clindamycin)

Rating: 4.8

Dalacin-gel

This local remedy in the form refers to antibiotics from the group lincosamides, and is a monocomponent medicine. This one the antibiotic acts quickly in the ducts of the sebaceous glands, since activated by skin enzymes. Sensitive to his action almost all known strains of propionic bacteria. Second Clindamycin will have a positive effect on reducing oily skin. by reducing the amount of fatty acids. Apply gel it is necessary in the same way as Zenerit, 2 times a day, applying it thinly a layer on the surface of acne. The course of treatment is long. First the results will be noticeable at least a month and a half, and the duration of the course of treatment can reach up to 6 months. American company produces this highly effective gel. Upjon, and a tube weighing 30 grams costs 925 rubles.

Attention! When buying Dalacin, do not confuse, because he It is also available in the form of a cream, but the cream is intended only for intravaginal use. This is all the more important because the cost gel and cream are almost the same, and it is very easy to get confused.

Advantages and disadvantages

The advantage of Dalacin can be considered its high activity and the ability to dry the skin without clogging pores, simply due to decrease in the secretion of fatty acids. When treating, you must consider the fact that combined use of clindamycin and Erythromycin should not be given since a phenomenon is observed between them. antagonism. Clindamycin can often cause applying to the skin the development of dryness and irritation. In the treatment it is necessary to carefully avoid applying the product to the conjunctiva eye and oral mucosa. If this happens enough often, and clindamycin will systematically enter the mouth, then severe and prolonged diarrhea is possible.

Klenzit C (clindamycin + adapalene).

Rating: 4.8

Klenzit S

This is a combination drug, which, in addition to the already mentioned clindamycin contains adapalene. This substance belongs to retinoids, relatives of vitamin A. It is known that they highly effective in the treatment of acne, and have a pronounced anti-inflammatory effect, eliminate the so-called comedones. Comedones are cystic enlargement of the mouth of the sebaceous glands, which were clogged thereby badly exfoliating superficial epidermis, and to blame for their formation hyperkeratosis.

Comedones for acne are a risk factor that leads to a chronic process and retention of inflammation in depth skin. It adapalene improves the cellular composition of hair follicles, which reduces the likelihood of clogging. Besides, Adapalene reduces the severity of cellular inflammatory reactions. The second component is again clindamycin, which was mentioned above. Together, these two components produce a more pronounced effect, than one by one.

Apply the drug to dry and clean acne once on night. You can notice the effect of the application on average after two weeks, the course usually lasts no longer than a month under supervision dermatologist. Persistent improvement develops after several courses, total duration of about 3 months.

Produces gel Klenzit S pharmaceutical company Glenmark from India, and the average cost of a tube weighing 30 g is 830 rubles.

Advantages and disadvantages

Advantages of Klenzit S – a combination of two highly active components in one relatively inexpensive tool. Medicine It is highly effective because it should be applied only once a day, resulting in significant savings. However, the drug can cause side effects, mainly due to clindamycin. Klenzit C is contraindicated during pregnancy and lactation, and is prohibited for use in patients suffering from Crohn’s disease, under 12 years old, due to lack of necessary research.

Baziron AC (benzoyl peroxide)

Rating: 4.7

Baziron

This drug with a pronounced antimicrobial effect represents a gel, but not colorless, but white. It is produced in a tube weighing 40 g, both at a concentration of 2.5% and 5%. Cost of these two varieties are approximately the same: 900 rubles per pack. Famous French company produces acne medicine Galderma. Baziron has not only antimicrobial, but also keratolytic action, removing excess keratinized skin. it allows you to eliminate the formation of cysts, or comedones, improve blood supply to tissues and reduce the synthesis of sebum. Apply Baziron AC follows from one to 2 times a day on dry and clean skin, the effect will be visible in a month. Persistent clinical remission usually occurs three months after treatment.

Advantages and disadvantages

Plus Baziron AS is a double action: keratolytic and antiseptic in one. Benzoyl peroxide has a very low resorption coefficient, and even if it gets through the skin, then quickly excreted by the kidneys and does not accumulate in the tissues. The medicine is not has a harmful effect on the fetus, and can be used during pregnancy and lactation. Adverse reactions include lung redness, dryness, or burning of the skin, which usually do not require cancellation. As in other cases, Baziron should not be applied to conjunctiva of the eyes, mucous membranes of the mouth and nose, and due to accidental If they get in, wash them with plenty of water. Price the range of this medication is medium (among treatments acne), quality – European. Baziron can be combined with other topical preparations as it does not contain antibiotics.

Skinoren (azelaic acid)

Rating: 4.6

Skinoren

Skinoren is a highly effective dermatoprotective agent, which protects the skin from microbial aggression and is used in quality gel and cream. The cost of cream and gel (30 g) approximately the same: about 1400 rubles. Azelaic acid action – improvement of keratinization function in the sebaceous glands, lowering oily skin and antimicrobial activity. Moreover, Skinoren does not considered an antibiotic. The tool also provides anti-inflammatory effect, regulates cellular immunity.

Apply the cream to pre-cleaned and dried skin, rubbing lightly, 2 times a day, preferably in the morning and in the evening. Economical: for application on the entire area of ​​the face a strip of about 2 cm long is sufficient. With acne vulgaris, usually clinical improvement is noticeable after a month, but the course should be longer, usually two or three months. Skinoren releases famous pharmaceutical company Bayer.

Advantages and disadvantages

The advantage of Skinoren is the possibility of its wide use in cosmetology, it is not only anti-acne means. It has been used successfully with rosacea. Skinoren is having antimicrobial effect and does not have side effects antibiotics. Skinoren does not require UV protection for the skin radiation during treatment, and is successfully used in integrated treatment of various types of acne, ranging from vulgar and ending heavy.

The best remedies for reducing inflammation and repair

Some tools discussed in the previous section of the rating already has anti-inflammatory components in its composition. But there are special prescriptions that provide anti-inflammatory effect, and at the same time do not contain antibacterial components and antibiotics. However, and in in this case there will be an antiseptic effect, but at the expense of others ingredients. They can be sulfur preparations, boric acid. Also widely used antifungal drugs that are used with a preventive purpose.

Curiosin – gel

Rating: 4.9

Curiosin gel

This gel, manufactured by the famous Hungarian company Gideon Richter, belongs to the reporters, that is, restores tissue, and stimulates her healing. Curiosin contains hyaluronic acid in combination with zinc. The use of curiosin promotes, in addition to improve tissue regeneration, reduce inflammation, a means It has an antiseptic and bacteriostatic effect.

The use of Curiosin improves local cellular immunity, promotes the correct differentiation of fibroblasts in the focus inflammation. The introduction of zinc in combination with hyaluronic acid allowed to obtain activity against pathogenic microorganisms, which is not observed when using other hyaluronic acid compounds (e.g. sodium hyaluronate). First of all, curiosin is indicated if the patient there is a large number of comedones, pustular acne, that is in the presence of a vesicle rash containing pustules, or pustules.

Prescribe this remedy for uncomplicated acne It is recommended immediately after reducing inflammation, and after manifestations of the action of antibacterial drugs. Availability hyaluronic acid allows the formation of minimal, cosmetic and inconspicuous scars, since the connective tissue with regular use of curiosin fills the entire defect skin. Apply Curiosin in the morning and evening, 2 times a day on clean affected skin. It dries fast enough, and the duration of the course of treatment is determined by the form and severity of acne rash. The cost of one package of gel weighing 15 g is, in an average of 570 rubles.

Advantages and disadvantages

Plus Curiosin is the ability to ennoble young scars, but for this it is necessary to apply it after the first fight with inflammation. Curiosin does not stain the skin, leaves no imprints on linen. The safety of Curiosin is high, with topical application practically not absorbed into the blood, and it is contraindicated only in case of individual intolerance, in pregnant and lactating women, but due to lack of data.

Delex – Acne, Blackhead Gel

Rating: 4.8

Delex - Acne, Acne Gel

We present in the rating, finally, the domestic drug. Manufacturer LLC Helsi – gel produces a whole line cosmetics. These are gels and lotions from acne, in the composition which includes plant extracts, menthol, as well as sulfur. The manufacturer does not describe in detail which plant formula contained, therefore, this tool and the entire line can not be considered medicinal, and parapharmaceutical. This gel and blackhead lotion not even used so much for treatment, but as with preventive purpose, and especially in patients with oily skin. As a result sebum production decreases, and in some cases Delex – acne gel is able to cope with acne, but only in in the event that it proceeds in a mild form.

Apply to the skin of the face one to two times a day. day, usually in the morning and evening. Do not rub the gel, but you can only impose. In the event that the gel is used to treatment, then it needs to be applied only to areas with acne rash, not on healthy skin. The manufacturer does not limit Duration of use: from week to up to complete disappearance of symptoms of inflammation. It costs one pack volume of 30 ml on average, about 210 rubles.

Advantages and disadvantages

The disadvantage of this drug is the fact that it a cosmetic product, not a medicine, and by strict rules rating of the best means it should not be in it at all. But nevertheless, we will make an exception for him, since acne there are periods of not only exacerbation but also remission, in this time and requires skin care with a preventive purpose. That prevention is considered the strength of all parapharmaceutical preparations, including this line funds. Cope with a fairly pronounced acne this gel or lotion is not capable of rash. The fact that the manufacturer did not limit the duration of the course of treatment, indicates that especially the drug does not have a strong effect. But then it’s available in pharmacies, well tolerated, has no contraindications, except individual intolerance, has a very low price.

Bioderma sebium AKN

Rating: 4.7

Bioderma sebium AKN

Another example of high-quality parapharmaceuticals used for the treatment and prevention of acne. This tool Available in two forms: cream and face emulsion. This the preparation contains alpha hydroxyacid esters that possess ability to dissolve comedones, and in cosmetics are used for so called acid or glycol peeling. Source alpha hydroxy acids are considered natural weak organic acids. These include, for example, apple, citrus and milk acids. The emulsion also includes beta-hydroxy acid, and it is salicylic. This tool has long been used in medicine as keratolytic drug, it normalizes follicular keratinization, preventing hyperkeratosis, improves exfoliation dead particles of the epidermis, and has anti-inflammatory effect.

Apply this emulsion to pre-cleaned skin once, once or twice daily daily, be prescribed for acne patients they should be within a few weeks after stopping exacerbation. It is desirable to carry out treatment under the guidance of an experienced dermatocosmetologist. Emulsifies the famous French company Bioderma, and a 30 ml tube costs an average of 1000 rubles.

Advantages and disadvantages

Bioderma is a very good parapharmaceutical and it is ideal will prevent the formation of new blackheads and comedones, but only if inflammation is first cured. Therefore, before you purchase this tool, you must consult a dermatologist or dermatologist, and find out if Do you need a comprehensive treatment at first? You can do it yourself get confused because there are tools that include different concentration of hydroxy acids. So, high concentration used for peeling, medium concentrated – are prescribed for a longer period, and drugs with low acid concentrations are shown in the inter-relapse period, as well as for scarring prevention. In the same case, if after curing acne if the so-called “problem” skin remains, this means for Care will be perfect.

The best drugs of the systemic effect: contraceptives, retinoids, antiandrogens.

Finally, we proceed to the description of “heavy artillery”, or systemic drugs. They are applied exclusively as directed by the doctor, and almost all are prescription. These are quite serious means. Among them contraceptives, or contraceptives, affecting male sex hormones and inhibiting their activity (strict antiandrogens), as well as systemic retinoids, from of which Roaccutane will be the most active – the “gold standard of treatment” severe acne. Consider these tools in more detail. In that section of the rating we will not list in detail each of the many drugs within groups because their specific selection is carried out only by a doctor. We give one characteristic and the brightest representative.

Jes (Yarina, Jeanine)

Rating: 4.9

Yarina

Needless to say, hormonal contraceptives in general originally created for women, and not just to prevent pregnancy, but also to normalize the cycle, and therefore these funds used only for the treatment of female acne. Known that the activity of the sebaceous glands, and related subsequent excretory duct obstruction and inflammation are regulated by activity male sex hormones, testosterone.

Therefore, the use of certain drugs (Jes, Yarina) with blocking androgenic action from this group allows reduce the severity of acne and the manifestation of secondary inflammation. These funds are quite effective, they are able to treat acne that has already arisen, as well as reduce the formation of new elements. Since all of these medicines are initially considered contraceptive, then their appointment should not be only with side of the dermatologist. The use of contraceptives Jess and its analogue- Yarins should be monitored by a gynecologist.

The drug Jess, except for contraception and treatment of severe forms premenstrual syndrome officially indicated for treatment moderate acne. This applies Jess to rather complicated scheme, which we will not describe here. For of this there is a special rating of contraceptives, to which we and send the reader. This medicine costs from 1000 rubles per packaging, which is designed for a month of admission, and produces it German company Bayer.

Advantages and disadvantages

Of course, the main drawback of all hormonal drugs will be strict indications and the need for medical supervision. Also these serious side effects may also occur. for example, associated with the development of thrombosis and vascular complications. But if there is evidence, there is a choice. Drugs Jess and Yarina identical in composition, but the concentration of hormones in the first of them is smaller than the second, and is proportionally reduced the risk of side effects, and Jess acts more gently.

But the drug Yarina acts more strongly, cleansing the skin faster from elements of acne, but at the same time its use is associated with higher risk. Of course the perfect destination the drug is a combination of direct indication, that is the need for hormonal contraception and the simultaneous presence acne. Also, hormone medications are great for everyone. patients with functional impairment the menstrual cycle and the development of acne, in which case hormonal funds will help establish a normal cycle and along the way rid of blackheads.

Systemic retinoids (Roaccutane, Aknekutan, Sotret)

Rating: 4.8

Roaccutane

We talked a bit about retinoids in the description of local remedies actions. So, the drug Klenzit-s in its composition is adaptal, which is a mild action retinoid. Roaacutan significantly more powerful. It acts by suppressing the activity of producing cutaneous fat, with a pronounced anti-inflammatory effect on the skin, effectively fights against hyperkeratosis of epithelial cells. Roaccutane improves the process of differentiation of skin cells.

This remedy is indicated only for severe types of acne, which are absolutely not sensitive to other types of treatment. Roaccutane should be used with food once or twice a day, in the treatment process is the selection of a dose. Quite often succeed achieve very good results in four or six continuous months of treatment, during which gradually selected individual dose.

The standard dosage for most patients does not exceed 1 mg per kilogram of body weight per day. The average course dose is 135 mg per kilogram of patient body weight throughout the course. One a pack of 30 capsules, 100 mg each, costs an average of 1800 rubles. Produces Roaccutane company Hoffmann la Roche from Germany. According to calculations, for a patient with an average body weight of 70 kg during the course, you need to take 9450 mg of Roaccutane. Accordingly, this is 94 tablets, or 5640 rubles for the entire course lasting three months, about 1900 rubles a month, which is not very expensive for the successful treatment of severe skin lesions.

Advantages and disadvantages

Perhaps the advantage of Roaccutane is the fact that it is – one of the last lifesaver for severe acne skin rashes that are completely refractory to all other methods of treatment. The high cost of the drug, divided into several months of reception, it turns out not so much big. Much more serious are the side effects that it can to call. Roaccutane in this sense is a very serious drug.

So serious that before starting treatment a woman who has sex, she needs to submit a certificate from a gynecologist that she is not pregnant. Also, the patient should bring written consent that she understands the danger pregnancy, fully informed about possible the consequences of pregnancy, and bring a certificate that already a month (!) before the scheduled intake of Roaccutane, she began to take contraceptives, and preferably two different means contraception. At least 11 days before starting to take Roaccutane the test should confirm the absence of pregnancy, and such sex testing should be done monthly during treatment. Why are all these unusual for any drug conditions?

The fact is that isotretinoin is not only highly effective. a drug for treating severe acne, but also a remedy, which can not only cause congenital malformations of the fetus, but almost guaranteed to cause them. In case if Roaccutane or its analogues are prescribed to men, then the patient should completely exclude the possibility of receiving at least one – the only pills for use by women. Therefore with men much “easier”.

It should also be remembered that with the treatment of acne usually after 10-15 days, an exacerbation of the disease occurs, and this is normal. But throughout the entire treatment period, the entire skin becomes very sensitive, prone to wounds, abrasions, so you can’t carry out planned operations and you need to try not to get injured. While the patient is taking Roaccutane, you can’t sunbathe, take alcohol, quite often a side effect such as dry lips and mucous membranes is a sign of vitamin A hypervitaminosis. In very simple words, then synthetic system retinoids are a means of introducing a patient into artificial hypervitaminosis, which helps get rid of acne.

Cyproterone (Androcur)

Rating: 4.7

Androkur

Finally, in conclusion, the ranking of effective drugs drugs to treat acne, or acne, should be highlighted infrequently used individual antiandrogenic drugs. Above already oral contraceptives have been described, with some blocking effect on androgenic activity. But antiandrogens specifically designed to block the effects of testosterone. Initially, drugs used to treat malignant neoplasms prostate gland because the prostate is an organ extremely responsive to changes in male concentration sex hormones. The most famous of the group of these tools is Androkur.

Officially, the indication for the use of the drug Androkur or its analogues in women – hirsutism, androgenic alopecia, and severe forms of acne. It should be noted that acne treatment possible only with a minimum dosage – it is 10 mg. The fact is that 50 and 100 mg tablets are on sale, they are created specifically for the treatment of prostate cancer, to reduce sex drive for sexual dysfunction, as well as for others special purposes not related to acne.

In women, the drug is used in conjunction with hormonal contraceptives, for example Diane-35. The purpose of this combination is to prevention of bleeding in women for taking antiandrogens. Itself It goes without saying that treatment control with a dermatologist should be carried out by a gynecologist, as women take Androkur on certain days of the cycle, and according to special rules.

The famous company Schering produces Androkur, and the cost is 15 tablets designed for monthly intake in the appropriate a dosage of 10 mg is, on average, 1,500 rubles. They apply daily in the first 15 days of the cycle, and then the contraceptive is connected Diana – 35.

Advantages and disadvantages

Perhaps Androkur is an alternative to Roaccutane in severe forms of acne, but only in women. If you take men, then practically all will prefer to use Roaccutane. Better protect your skin, and have a risk of developing any systemic effects than losing time for treatment of male sexual characteristics, to acquire impotence and on long term suppress sex drive. After all, usually antiandrogen drugs for men are shown only for very a serious occasion, for example, the goal of prolonging life in severe, inoperable forms of prostate cancer.

In conclusion, it should be recalled that it is better from the very beginning to properly deal with the first manifestations of acne in youth age, and not bring the matter to severe forms. To this end regular hygiene procedures are recommended, it is important to follow principles of proper nutrition. Very important to keep healthy skin is a complete rejection of bad habits.


Attention! This rating is subjective, not advertising and does not serve as a guide to the purchase. Before the purchase consultation with a specialist is necessary.

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