Review of the best according to the editors. About the selection criteria. The the material is subjective, is not advertising and is not serves as a guide to the purchase. Before purchase is needed consultation with a specialist.
In an article on sleeping pills, we talked about how to deal with insomnia in order to relax comfortably and fully. Surprisingly, in the Russian Federation, the treatment of insomnia set at a much better level close to the world than reverse situation. Anti-drowsiness drugs activating agents, psychostimulants that are free sold in Western countries, in our country are not available, since they are included in the list of narcotic substances and their precursors. Therefore, you have to cunning, and do “grandfather” ways.
If in the article about the treatment of insomnia one could talk about groups of drugs, about a great choice for the attending a doctor, both prescription and over-the-counter drugs, then in treatment the drowsiness possibilities of domestic medicine are much more scarce. However, first things first. First, let’s talk about why excessive drowsiness occurs, what forms are found and how they are called how it should be correctly diagnosed.
Indeed, quite often the patient needs to take completely different medications that will help him, and not at all remedies for drowsiness. For example, thyroid deficiency causes hypothyroidism, the characteristic symptom of which will be constantly daytime drowsiness and lethargy. Such a patient does not need to be treated at all. drowsiness by psychostimulants. It’s enough to normalize it hormonal background and when the concentration of thyroid hormones reaches the desired values, then such pathological drowsiness will pass by itself. Similarly, it can happen in others. situations, so even a person without a medical education it is advisable to know the causes of excessive drowsiness so that promptly contact an experienced specialist. How is it determined modern science excessive drowsiness?
- What is hypersomnia and what are its causes
- Causes of hypersomnia
- Kleine Syndrome – Levine
- Idiopathic hypersomnia
- Group of secondary hypersomnia
- Drug drowsiness
- Drowsiness in Mental Disorders
- Lack of sleep syndrome
- Diagnostic Methods
- Drowsiness treatment
- The best remedies for drowsiness
- Domestic psychostimulants
- Advantages and disadvantages
- Advantages and disadvantages
- Venlafaxine (Velaxin, Velafax, Venlaxor, organic venlafaxine)
- Advantages and disadvantages
- FDA Approved Medicines (USA)
- Sodium Oxybutyrate (Xyrem)
- Modafinil (Provigil)
- Solriamphetol (Sunosi) and pitolysant (Wakix)
- Levothyroxine (Synthroid)
- Melatonin (Melaxen)
- Instead of a conclusion
What is hypersomnia and what are its causes
Excessive drowsiness at a time when naturally full wakefulness and activity is supposed, called hypersomnia (remember that insomnia is called insomnia disorder).
At the same time, increased daytime sleepiness is a condition when a person does not manage to be active most of the day.
The second criterion for daytime sleepiness is when a person falls asleep against my will in the afternoon, and for three months there is at least one such episode, and then a condition repeated. In other words, during the year there must be at least 4 episodes of accidental falling asleep during the day, what could we talk about the presence of prolonged hypersomnic disorder.
In the international classification of sleep disorders to excess pathological drowsiness include the following diseases and conditions: narcolepsy, Kleine-Levin syndrome, idiopathic hypersomnia and a whole group of secondary conditions. Tell about them in more detail.
Causes of hypersomnia
Pathological drowsiness does not always occur. She can to be in healthy individuals, if a person has not slept for a long time, if he experiencing anxiety, or nervous stress, and are also under the influence of large doses of coffee. But there are special, painful condition. These are narcolepsy, Levin syndrome and idiopathic hypersomnia. In this case, no external causes that could affect drowsiness is not detected, it’s actually primary sleep disorders. Let’s get acquainted with them in more detail.
Narcolepsy is the most famous of these diseases. For Narcolepsy is very characteristic of several classic signs. At patients have pronounced daytime sleepiness, desire to sleep can be so irresistible that it’s called imperative, or imperative, and the patient periodically immerses in the daytime a dream that he cannot control.
There is a significant decrease in muscle tone, or complete muscle lethargy called cataplexy. Often there are daytime attacks of such cataplexy, or muscle lethargy, while falling asleep and waking up, the patient can see bright visual visions or images that are hallucinatory. The patient, during waking and falling asleep, also experiences a sharp decreased muscle tone, and nightly sleep in such people in heavily disturbed.
The main symptom, which greatly affects the quality of life, and even leads to disability – an irresistible need sleep during the day, and frequent episodes of falling asleep. The patient can sleep from 2-3 minutes, and up to several hours. After such an awakening it’s easier for the patient, and he is more active than before, but not for long: then drowsiness intensifies again.
It is characteristic that such attacks occur when a person is not need to actively participate in some kind of process. This is a trip to by public transport, being in the cinema, reading. Attempt doing gymnastics, taking a shower or jogging is capable of suppress the desire for sleep, but sometimes attacks of drowsiness are very bright and sudden, for example, with food or even when walking.
In this case, patients have significant problems at night. Yes, they fall asleep quickly and well, but after that they sleep short periods of time, often wake up, with repeated falling asleep already difficulties arise, at night the dream is not calm, with high motor activity. Moreover, in patients during sleep, it can be expressed teeth creak (bruxism), restless legs syndrome and others pathological phenomena. It remains to add that such people quite often there is overweight, the presence of chronic anxiety or depression, there are episodes of panic attacks and pathological fatigue.
Kleine Syndrome – Levine
This is a very rare disease, also called syndrome. periodic hibernation. Drowsiness is very difficult, constant and lasts a long time, on average, 10-15 days. There are severe cases, when hibernation lasts for several weeks or even months. Such periods of drowsiness tend to recur, while the patient sleeps up to 20 hours a day, and rises only to eat and go to the toilet. Therefore, do not confuse this disease. with lethargic sleep. Being in a lethargic dream, people do not wake up at all, do not go to the toilet, they have a metabolism slowed down and they can resemble for long days and weeks dead man. Patient with Kleine-Levin disorder daily should spend at least several hours in active able to eat and go to the toilet, which means that his metabolism and metabolism remain normal level.
If during a hibernation period a person wakes up, then he remains lethargic, sleepy and lethargic. During such a period of sleep the patient does not remember what happened to him the day before, poorly perceives the world around us can be gluttonous, hypersexual and disturbing. During such an attack, a person for many days falls out of social life and his profession, spending these days in the bed. In this case, no physical changes in the work of internal organs and deviations in the analysis does not exist. Between such with hibernation, a person leads a perfectly normal life.
It should be recalled that this is an extremely rare disease, and among 140 million people living in Russia, there are hardly 50-60 a person with such a diagnosis because the incidence rate in an average of 1 in 1,000,000 cases, excluding infants and the elderly. With episodes of pathological drowsiness occur less frequently and less often, and on average, 15 years after the first attack becomes normal. In men, with an early onset of pathological drowsiness under the age of 12 years, the disease progresses a little longer.
This is a disease in which there are not a lot of symptoms, and daytime sleepiness exists randomly and randomly, no there is no cataplexy, or a decrease in muscle tone of these patients, they also have no hibernation periods. Duration of night sleep they are ordinary, no night insomnia.
Such individuals have the phenomenon of difficulty waking up, and sometimes so-called carotid intoxication, or sleep inertia, develops. At trying to wake these patients up, they become irritable, consciousness is confused, their behavior may differ in automatism. Such sleepy inertia can last about an hour. When are they wake up, then note that they are still in a broken condition, and the previous dream did not bring them relief. Such patients quite often there are disorders of the autonomic nervous systems, headache, vascular disorders.
Most often, women get sick, the disease begins on average age – 18 years, and idiopathic hypersomnia most often It occurs in the form of family cases. To the complications of this disease social consequences apply. This is the possibility of job loss, decline in performance, decline in social status and so Further. However, social consequences are dangerous for all primary hypersomnia.
Group of secondary hypersomnia
Secondary hypersomnia differs from primary hypersomnia in that the centers sleep and wakefulness located in the brain do not suffer, but the cause of pathological drowsiness is another somatic a disease, for example the same hypothyroidism or myxedema. Symptoms are the same: daytime drowsiness, daytime falling asleep, prolonged sleep at night, and other symptoms. The main task doctor – find out the reason that caused excessive drowsiness. Most often, it is a disease of the central nervous system. Metabolic encephalopathy, chronic poisoning, consequences encephalitis, brain tumors, sarcoidosis. Special the appearance of drowsiness is typical for volume formations, which affect the hypothalamic region. There is excess daily drowsiness in both Parkinson’s disease and various genetic hereditary diseases. Consider some of the most common occurring secondary hypersomnia.
This is the most common group. Many drugs have concomitant sedative effect, and most often it is a sleeping pill drugs that are unsuccessfully selected and continue to act in the afternoon. These are benzodiazepines and barbiturates. Perhaps development drowsiness when taking anticonvulsant drugs for treatment of epilepsy, antiallergic drugs, especially rude, first generation. This is Suprastin, Tavegil, Diazolin, diphenhydramine. There is drowsiness and the reception of non-steroidal anti-inflammatory drugs, some antiarrhythmic funds, and beta blockers. Very often drowsiness occurs during the day in elderly patients who take a large amount at once different medicines for heart disease. In some cases drug drowsiness may be caused by taking anticholinergics and certain antidepressants.
Drowsiness in Mental Disorders
If a person is registered with a psychiatrist, then he can also daytime sleepiness is also expressed. Her reason may be severe depression, bipolar disorder that used to be called manic-depressive psychosis. Approximately every 20th a patient with persistent daytime sleepiness has any cause mental illness. Such patients have a long time falling asleep, they often wake up, and inside sleep they have wakefulness phase, and although the patient is in bed longer than necessary, the effectiveness of such a dream is reduced.
Lack of sleep syndrome
Finally, syndrome refers to secondary hypersomnia lack of sleep. It arises if artificially this dream limit, and sleep less than the body needs. Arises persistent conflict between the body’s need for rest and actual duration of sleep. Patients quite often do not understand that their long work, and short sleep time can cause severe drowsiness during the day. But the syndrome is not so drowsy limited to. There is malaise and anxiety, lack of vital energy and decreased motivation, low appears activity and carelessness. Such patients are irritable. Of course, you need to fight with insufficient sleep syndrome a change in regimen, and all symptoms regress if duration sleep increase at least up to 7 hours a day for a long time. Naturally, insufficient sleep syndrome is most often affected teens, young people and students.
If you think it’s enough to complain about daylight drowsiness, and the diagnosis is already clear – then this is not at all true. First on see a somnologist, or a specialist in sleep disorders, need to talk about your complaints, and answer questions special profiles. There are special international scales. drowsiness, such as Stanford and Caroline, these methods studies are subjective, because the patient himself can affect their accuracy.
Then sleep disorder must be objectified using other instrumental methods. This is a multiple test. sleep latency, polysomnography and other methods. So, the test for sleep latency is exploring a person’s ability to fall asleep in the usual calm environment. First polysomnography is performed, she proves that before the study the patient had a normal period previous night’s sleep for at least 7 hours. Then a test is done, which for an adult and a healthy person usually exceeds 10 minutes. That is, lying in the afternoon in a calm, relaxed atmosphere, a person who sets out to fall asleep will not fall asleep earlier than in 10 minutes. But in a patient with hypersomnia, or with drowsiness, this time is much shorter, and diagnostic importance occurs when less than 8 minutes in duration. There are other instrumental research methods that must be passed for confirmation or refutation of the diagnosis of hypersomnia.
First, we will consider those drugs that you can safely buy in any Russian pharmacy without a prescription, and which will somewhat activate patients and increase them vitality. This is a group of adaptogens. After that there will be those drugs that can also be bought in pharmacies without recipe, but it will not be adaptogens, but synthetic ones medicines, for example the safest and most effective caffeine. Finally, the last group will include all the most highly effective pills that are used abroad, and sometimes used not only to treat various forms drowsiness, but also to enhance intellectual potential.
These medicines are sometimes used by students, and even by scientists. workers to perform critical work, these medicines increase vigor and stimulate the central nervous system. Exactly by this they caused concern of the corresponding “organs”.
For each drug will be possible Indicated international nonproprietary name, or INN. If a there is an original representative that was developed and implemented in clinical practice first, then its name will be given immediately after the INN. In the case of generics, or commercial copies will also list the most famous ones, and will given the price range for some drugs. Price relevant for pharmacies of all forms of ownership in the territory Russian Federation for October 2019.
The best remedies for drowsiness
|Nomination||a place||Name of product||price|
|Domestic psychostimulants||1||Caffeine||48 rub|
|3||Venlafaxine (Velaxin, Velafax, Venlaxor, organic venlafaxine)||217 rub|
|FDA Approved Medicines (USA)||1||Sodium Oxybutyrate (Xyrem)||1 109 rub.|
|2||Modafinil (Provigil)||3 500 rub.|
|3||Solriamphetol (Sunosi) and pitolysant (Wakix)||3 500 rub.|
|4||Levothyroxine (Synthroid)||83 rub|
|5||Melatonin (Melaxen)||370 RUB|
With adaptogens, a drug fight against drowsiness begins. Adaptogens are called tonic herbal medicines origin that increase metabolism and adaptation organism to changing environmental conditions, and therefore their called so. There are many of them. This is Chinese lemongrass, ginseng, Rhodiola rosea, Leuzea, Aralia, even decoction and tincture rose hips and echinacea.
All of these drugs are usually sold in liquid form. in the form of extracts and tinctures, and are inexpensive. Mechanism of their influence on the body is not completely clear, but their effects are well known. The tone of the body is gradually increasing, and its life activity. Metabolism is activated, also occurs activation of autonomic and endocrine function.
How is this general tonic effect manifested? The patient increases the secretion of the glands of the gastrointestinal tract, increases appetite, increased heart function, slightly increased pressure. In addition to such a general manifestation on organs, there is also a small psychostimulation. Of course, her level is not as high as that of foreign drugs, for example, related to derivative amphetamines. But still, in mild cases, such psychostimulation allows you to fight well with drowsiness. The patient increased performance, both physical and mental. Fatigue decreases, asthenic manifestation decreases. syndrome.
It is very important to emphasize what psychostimulant and the general tonic effect is very mild and can be considered within the physiological norm. No getting used to no excessive excitement, and especially euphoria, adaptogens do not have. A very important side but beneficial effect can be consider increased immunity, low toxicity, good tolerance, and the absence of significant side effects.
In addition to plant materials, pantocrine should also be called, which is obtained from the young horns of deer (Altai deer). TO adaptogens also include propolis, mumiyo, various vitamin complexes that contain their additives, for example, Doppelherz Ginseng, Bittner’s Herbal Elixir, Chinese Balm “Golden Dragon”. Various bath salts are available containing adaptogens, coniferous extract. It makes no sense to list in detail advantages and disadvantages of individual representatives about genes should have common concepts, since they are all sold over-the-counter, and their can be used as first-line drugs in the fight against excessive drowsiness.
Why is this section called “domestic” psychostimulants? Because imported psychostimulants are prohibited. On their trouble, many drugs belong to amphetamines. But their introduction into similar lists restricting their circulation – a measure very short-sighted and stupid. In the country, drug addiction has gradually become cheaper, there were chemical and salt substitutes, the number drug addicts are not decreasing, and the metropolitan “elite” indulges in clean cocaine. In this light, expensive drugs are not possible help patients, and addiction continues to flourish.
Psychostimulants, which we sold not so long ago, much weaker than amphetamines, such as mesocarb, or Sydnocarb. This drug could already be prescribed by prescription and by domestic experts, but unfortunately, he ended registration, but did not renew it, which is again targeted policies leading to health disruption. Finally, only the derivative of psychostimulants remains for Russians methylxanthines, or regular caffeine. It is sold in solution and in pills, and helps pretty well with regular, not heavy bouts of drowsiness and loss of strength. There are other medicines pharmacological groups that are not related to adaptogens, but we we will not consider here.
Consider only Sydnocarb and caffeine. Domestic specialists in the fight against insomnia use other medicines like duloxetine and venlafaxine from the group of antidepressants, selective reverse inhibitors serotonin uptake. This is not very convenient because venlafaxine acts short, and in the fight against drowsiness is more appropriate sustained release. Another antidepressant may be used. – Fluoxetine, the use of which is justified if available depressive or anxious state against the background of narcolepsy.
It is important to remember that abrupt withdrawal of these drugs may increase decreased muscle tone, or cataplexy up to severe a condition called cataplexic status. Of all medications, only caffeine can be safely bought at the pharmacy without any prescription. The action is with him, though quite weak, we will start with it.
Popularity Rating: 4.9
The invigorating effect of caffeine is familiar to everyone. This alkaloid contains and in tea leaves, and in coffee seeds, and in stake nuts, of which both a real Coca Cola is being made. It excites the central nervous system, improves performance, reduces latency reactions. For a while, drowsiness is eliminated and reduced after caffeine intake. It increases the strength of the heart, increases pressure, and causes increased diuresis. After a cup of strong coffee more urine is formed.
In small doses, caffeine has a stimulating effect, but large – on the contrary, it depresses, and is able to provoke drowsiness. It affects the body of the elderly more than young people. For drowsiness, it is used in a dosage of 100 mg in the morning and 100 mg, same dose, at lunch. It cannot be prescribed in large doses, more than 3 tablets, i.e. 300 mg per day. It is equivalent to 4 large cups of pretty strong coffee.
Tableted caffeine (caffeine-sodium benzoate) costs a lot inexpensive, but the package contains only a few pills. A pack of 10 tablets of 100 mg of caffeine will cost from 40 to 70 rubles., This is domestic production – Tatkhimpharmaceuticals. There is a dosage and twice as much, 200 mg No. 10, and The cost of this package is also about 60 rubles. Produces it Borshchagovsky chemical farm in Ukraine.
Advantages and disadvantages
The advantage of caffeine is that it’s natural, fast-acting drug without side effects, if not increased dose. If the dose is high, then a pathological agitation, getting rid of drowsiness will turn into insomnia, will tachycardia, increased blood pressure and other unpleasant effects. Do not take caffeine in high pressure, on glaucoma, as well as heart rhythm disturbances. Unconditional the plus is the soft effect, low cost, and for lovers, that do not tolerate coffee, a caffeine tablet can completely replace Feels like a favorite drink. There is also an undeniable advantage. If you want vigor and clarity of thinking, for example, during pass the exam, you can just buy it without a prescription completely free.
Popularity Rating: 4.8
Sydnocarb and its counterpart – Mesocarb is much stronger psychostimulant, it stands approximately in the middle in activity between caffeine and banned amphetamine derivatives in Russia. Shown Sydnocarb for use, except drowsiness, with lethargy, decrease efficiency, inhibition and asthenoneurotic syndrome. It helps in the treatment of various serious illnesses, intoxication and infections in the recovery phase. Also he used in the complex treatment of alcoholism and withdrawal symptoms syndrome, with mental retardation in children, in the case of organic diseases of the central nervous system. A drug taken once or twice a day, except in the evening, that is, in the morning and before lunch, before eating. The usual dosage is 25 mg per day, the initial dose – 5 mg.
Advantages and disadvantages
It is important to remember that the stimulating effect of this medicine develops gradually, and not immediately. This is good because no a sharp activating and exciting effect from the very beginning. At there is no drug euphoria, no motor excitement, no tachycardia and increased pressure, that is, side effects, peculiar to caffeine. Sydnocarb doesn’t have them. If you cancel it, then general weakness and drowsiness does not return, the appearance of addiction much less pronounced. However, the patient may have the development of such side effects like decreased appetite, insomnia, anxiety and incontinence.
Perhaps the most important unpleasant effect is its long-term lack of pharmacies in the Russian Federation, and practically ubiquitous. There is evidence that Sydnocarb has lost registration certificate, and now in Russia it is not for sale. It is quite unpleasant fact, saying that the domestic authorities health care uninteresting needs of patients. Therefore here This drug is only described because it is possible purchase it abroad, if there is evidence.
Venlafaxine (Velaxin, Velafax, Venlaxor, organic venlafaxine)
Popularity Rating: 4.7
Velaxin is a modern drug from the group of selective serotonin reuptake inhibitors, antidepressant. Besides drowsiness, it is indicated for depression, anxiety disorders. Use the drug once a day in a dose 75 mg, this may well be enough to activate the patient, but you can double the dose, be sure to take into account contraindications. The maximum daily dose of venlafaxine is 350 mg.
The company produces the cheapest domestic venlafaxine Organics – it can be purchased starting at a price of 280 rubles. behind a pack of 30 tablets of 75 mg. Recall that a pack of 28 Velaxin tablets, which is manufactured in Hungary by the Egis company, will cost from 950 rubles. If we talk about prolonged sustained release capsules that provide more long and comfortable struggle with drowsiness, they will already be cost more. Their price is from 1100 rubles. up to 1500 rub. for the same packaging.
Advantages and disadvantages
The medicine is contraindicated in persons with severe disabilities. liver and kidney, pregnant and lactating women, as well as aged under 18 years old. Care must be given to people with high blood pressure, including intraocular, and with glaucoma, low body weight and heart failure. Side effects include weakness, insomnia and agitation, lowering pressure, lowering platelet count, sweating, erectile dysfunction, violation of ejaculation in men.
FDA Approved Medicines (USA)
Such drugs can not be purchased in Russia, and you may face the criminal term, even when trying to import them into the country. They can contain amphetamine derivatives, and the same story may come out, as with the acclaimed Frizium. However the best known medicinal Modafinil is considered a remedy. In 2019, the United States was approved yet two drugs to treat drowsiness and narcolepsy, We will tell briefly about them. But let’s start with regular sodium hydroxybutyrate, or gamma hydroxybutyric acid.
Sodium Oxybutyrate (Xyrem)
Popularity Rating: 4.9
Sodium oxybutyrate (GHB) was very popular in surgical in hospitals, in the departments of anesthesiology and intensive care in nineties of the last century, and no special problems related with its turnover, did not arise. Now they are also completely unreasonably complicated, and sodium oxybutyrate is impossible to purchase either on sale or by prescription. The drug is very rarely found even in specialized hospitals.
This tool improves the duration of both quick and slow sleep, and very good for narcolepsy. In the afternoon he copes with drowsiness, is able to eliminate sleep paralysis, fights against hallucinations and reduces manifestations of cataplexy. is he acts very short, no more than 4 hours. Therefore, in order to sleep was physiological and full at night, you need to take it 2 times: before bedtime and in the middle of the night, specially waking up for of this. The initial dose is 4.5 g every day, then it can be increase by 1.5 g in a week. Maximum dosage sodium oxybutyrate is 9 g per day. Most often from side effects may include weight loss and nausea, and due to sedation in overweight patients may there is an increase in night snoring and the appearance of sleepy apnea, which may be associated with an increased risk to life.
Popularity Rating: 4.8
Modafinil is very widely used to combat drowsiness, although its mechanism is still not entirely understood. It is believed that he increases the concentration of monoamines in the structures of the central nervous system. The amount of dopamine increases in extrapyramidal formations in the hypothalamus increases the concentration of norepinephrine, increased production of serotonin in the cortex of the frontal lobes of the brain. Take it in the morning, at a dosage of 100 mg. Then attach the drug at noon, in the same dosage. The maximum daily dose is 400 mg.
As practice shows, a psychostimulating effect develops in 50% of all patients, and it is sufficient to combat drowsiness. However, sometimes a headache develops, especially in the background quickly increase dosage. If you raise it slowly, then this side no effect appears. Modafinil may also increase arterial pressure. pressure and increase anxiety, like all many remedies, who successfully fight drowsiness. As mentioned above, registration in our country of this drug is not, and not is foreseen.
Solriamphetol (Sunosi) and pitolysant (Wakix)
Popularity Rating: 4.7
These drugs are brand new, they got approval US Federal Agency (FDA) this year only. The first drug – for the treatment of drowsiness, including primary, narcolepsy and sleep apnea syndrome. Can be considered its creation revolutionary breakthrough, because the drug has a completely different pharmacological action other than psychostimulation. This is the first a registered dopamine reuptake inhibitor and at the same time norepinephrine, that is, a double-acting agent. Solriamphetol is also approved for the treatment of daytime sleepiness in adults.
You can name the second drug, pitolizant. This drug so far not yet available even in the USA as it has been approved by the FDA only only in August of this (2019) year. This medicine is an antagonist of histamine receptors of type 3, and its task is increase the synthesis and release of histamine in the brain. It is known that histamine is a mediator that stimulates wakefulness, and reduces drowsiness. This medicine, according to research, significantly reduced drowsiness in 30% of people with this disorder, which were resistant to other drugs. therefore in the future, Wakix may play the role of a reserve, or a means of a second lines for the treatment of primary hypersomnia.
Popularity Rating: 4.7
This drug is a synthetic thyroid hormone analogue and it is used in the USA for treatment of endocrine pathology. It is usually prescribed to people with myxedema, or with hypothyroidism. But studies have shown that this drug if used in patients with an early form hypothyroidism, with a slight decrease in the concentration of hormones, then he relieves daytime sleepiness, and also reduces average sleep time. It was a pleasant side effect. This drug is being modified, studied and improved, since he, despite his promising applications, carries a potential risk increase arrhythmias and their occurrence.
Popularity Rating: 4.7
About this substance, a synthetic analogue of the hormone melatonin already was written in other reviews when it came to the fight against insomnia Jetlage, that is, painful maladaptation when changing sentries belts. Melatonin is actively produced in the pineal gland, or pineal iron at a young age, and in the elderly, its production is gradually decreases. Melaxen may be indicated for daytime treatment drowsiness, but not in connection with its activating, or psychostimulating effect, but with improved quality physiological night sleep. Here we will not describe in detail manufacturers, effects and prices of Melaxen and its analogues, refer to relevant articles.
Instead of a conclusion
In fact, others may also have an activating effect. drugs that are designed to treat completely other diseases. So, is there a cure for selegiline, or a representative monoamine oxidase inhibitors (MAO). It is mainly used for Parkinson’s disease treatment, but it suppresses daytime drowsiness. Therefore, it can also be used for certain testimony.
Curious were studies that showed that ordinary the clarithromycin antibiotic also fights against daytime sleepiness and improved the quality of life. It is a macrolide antibiotic derivative erythromycin, it has long been used to treat various infections. His ability to combat daytime sleepiness has been proven in a true double-blind, placebo-controlled study in 2015, which was held in accordance with all the rules. A drug significantly reduced drowsiness and increased energy.
It should be recalled the categorical prohibition on the use of caffeine, taurine and their analogues with alcohol. All alcohol caffeinated cocktails, for example, “Yaga”, “Yagych”, that is the infamous “Jaguar” in banks, with regular use in 3-5 cans per day for six months leads to heavy, irreversible variants of alcoholic cardiomyopathy, which is often ended with a sudden death in young men, among seemingly full of visible health.
Of course, even in the case of primary hypersomnia, it is not necessary only drug treatment, but also individual adaptation, the right attitude to the disease and the development of adaptive skills behavior. It is very important to increase the patient’s self-esteem, and inform doctors about hypersomnia. This is an important medical problem. sleep, and still in our country, as can be seen from the list drugs, it is given insufficient attention.
Popularity rating based on analysis of demand data service wordstat.yandex.ru.
Attention! This rating is subjective, not advertising and does not serve as a guide to the purchase. Before the purchase consultation with a specialist is necessary.