8 best arthritis drugs

Review of the best according to the editors. About the selection criteria. The the material is subjective, is not advertising and is not serves as a guide to the purchase. Before purchase is needed consultation with a specialist.

Treating most arthritis is a “clean” therapy because all except very few arthritis are treated conservatively ways. Most often, arthritis is treated by physicians, and more “narrow” specialists are rheumatologists. Rheumatologists are needed if when joint inflammation is systemic, and is associated with disorders in the connective tissue and autoimmune pathology. Much less often inflammatory joint diseases are the lot of doctors infectious disease specialists and TB specialists, as there is, for example, brucellosis and even tuberculous arthritis. For example, in the case if an adult has an isolated, one-sided, long-term ongoing inflammation of the knee joint, i.e. asymmetric drives, it is almost always – tuberculous process.

Before talking about the drug treatment for arthritis, recall what it is, how arthritis differs from arthrosis, and how he happens. After all, speaking of arthritis, I mean a whole group various diseases.

What is arthritis, and what is it?

Arthritis is an inflammatory joint disease in which The main symptoms are the classic symptoms of inflammation. These symptoms have been known since ancient times, and their significance to the doctor until still not changed. Classic inflammatory signs which can be fully attributed to any arthritis are:

  1. redness or redness of the local area, which indicates hyperemia, or inflammatory blood flow to the joint.
  2. swelling, which also indicates swelling inflammatory in nature, which is caused by the reaction of tissue to exit biologically active substances in the focus of inflammation;
  3. local temperature increase, or a feeling of heat over affected joint. This is a very characteristic component of inflammation, and speaks of an increase in metabolic processes in the lesion;
  4. local soreness is one of the most important symptoms of arthritis, but the pain in the affected joint will not only be with arthritis, but also with arthrosis. Next, it will be said how to easily distinguish arthritis from arthrosis;
  5. finally, the last, fifth big symptom of inflammation characteristic of arthritis is a dysfunction. Violation functions are lameness, limitation of mobility, development stiffness in the joint, and so on.

All the symptoms of arthritis are extremely simple and clear, and all of them You can determine yourself, and very quickly. But sometimes they talk about arthrosis of the joint. How arthritis differs from arthrosis, and how not mix up these diseases?

Differences of arthritis from arthrosis

First of all, the end of the medical term. All medical noun terms that end in “–it” are name of inflammatory diagnoses: encephalitis, peritonitis, sinusitis, arthritis. All terms that end with “-oz” are already non-inflammatory diseases, in this case pathological growth and change of certain tissues. For example, sclerosis is a vascular pathology in which they become brittle and hard. Amyloidosis is a process of education pathological amyloid protein, chondrosis is a modification cartilage, in which cartilage becomes fragile and loses elasticity.

Finally, arthrosis is a joint pathology in which articular surfaces change, a crunch appears during movement, synovial fluid or lubricant production is reduced, and all this also leads to limited mobility in the joints and pain syndrome. But at the same time, arthrosis does not have such pronounced inflammatory signs. On the contrary, an attentive doctor may to distinguish between complaints of arthritis and arthrosis, even if not obvious redness of the skin and a local increase in temperature above affected joint.

Here are the characteristic features of this difference. In a patient with arthrosis joint pain occurs immediately after the start of movement, and then the joint is gradually “earned”. A very characteristic symptom is it’s an elderly man’s limp right after getting up in the morning with beds, he needs to disperse, and in the afternoon he gets better. IN in case of arthritis, the situation is reversed, the joint needs rest, and rest reduces the severity of inflammation, edema decreases, and then it becomes easier to walk, however, this does not last long.

Arthritis and arthrosis have characteristic various symptoms on x-ray, and ultrasound examination, as well as on tomography, but we will not dwell on this.

Arthritis can be classified in many ways. If struck one joint is monoarthritis, if several joints – then this oligoarthritis, if a lot – then it is polyarthritis. Arthritis may also be primary or secondary, depending on which the process led to inflammation. Joint inflammation may be infectious, for example, with the same brucellosis, or Lyme disease, inflammation may have metabolic character. A classic example is a gout attack, with a lesion base of the big toe. A large number of arthritis relate to systemic lesions of connective tissue, may have autoimmune, rheumatic origin. The classic example is it is rheumatoid arthritis.

If arthritis is of systemic origin and is a symptom lesions of the connective tissue, there may be other signs. This is a vascular lesion, hemorrhagic syndrome, vascular thrombosis, damage to the peripheral nervous system in the form of mononeuritis or polyneuropathy. The patient may have concomitant eye damage, the presence of dry or effusion pleurisy and pericarditis, and other severe symptoms. Such a diffuse lesion is treated seriously drugs. These are corticosteroid hormones, cytostatics and immunosuppressants, which will be discussed below. But in most cases of treatment of simple arthritis that are not complicated by pathology internal organs are treated much easier.

Pharmacotherapy, or Arthritis Medication

Since arthritis, as inflammation of the joints, is known with deep antiquity, and unlike inflammatory processes in the internal organs, all the symptoms can be seen with your own eyes, then the very first Arthritis treatment was carried out by folk remedies. Still the national custom has been preserved to apply burdock, or cold in place inflammatory edema and redness, which leads to relief. But this method of treatment is extremely symptomatic. character. Yes, withdrawal of symptoms is a very important stage of treatment, especially at the very beginning.

Naturally, the most important and unpleasant symptom that reduces quality of life, is an inflammatory intense pulsating or constant joint pain at rest, as well as when walking. TO Unfortunately, eliminating pain is not possible to affect inflammation, therefore, the main and main group of drugs will be be non-steroidal anti-inflammatory drugs, or NSAIDs. They stop the inflammation itself, and are extremely useful for arthritis wide. This is intramuscular injection, tablets, intraarticular introduction. To eliminate inflammation, especially chronic, patients can use local medications with NSAIDs are various ointments, creams and gels, liquid balms, bischofite, ozokerite, and other drugs that improve metabolism in the joints, and eliminate inflammation. You can use local funds at stages of persistent remission, and with exacerbation, and with acute process.

In addition to the classic regimens for the treatment of arthritis, there are those drugs that you can’t just buy in pharmacies. This is about modern treatment for severe arthritis that is treated for life. These are basic drugs, cytostatics, complexing agents and immunosuppressants widely used in rheumatology.

A large group of the most advanced treatments for arthritis and systemic pathologies make up the so-called monoclonal antibodies artificially created by molecular genetics. These are inhibitors of certain elements of inflammation, drugs that fight immune aggression, pathogenic function blockers lymphocytes and interleukin. All this can be called heavy artillery, and these medicines will be discussed in end of article.

It should be said that, in addition to drugs of the main series, always there are aids. So, if besides inflammation joints, muscles are affected, then central muscle relaxants are used, which reduce muscle cramps and reduce pain. If arthritis develops amid stress and generalized anxiety disorders, then pain will help to reduce pain antidepressants. If the patient does not tolerate anti-inflammatory drugs and he has a stomach ulcer or erosive gastritis, it is always used as a cover modern drugs for the treatment of ulcers, i.e. proton blockers pumps. In some cases, vitamins and trace elements, physiotherapeutic treatment, and regimen change joint load.

This article will discuss drugs which are the main ones. We will not talk about gastroprotectors, about antidepressants, for this there are separate articles, and we will begin the drug review with a large group non-steroidal anti-inflammatory drugs. For each the drug is first given international generic name (INN) and then the name the original drug and its generics, or commercial copies. Price ranges from the most expensive to the cheapest will be given. face value. Prices are valid for retail sale of medicines in autumn. 2019 in the Russian Federation. The order of listing of drugs is not is a rating scale or rating, they are located in random order according to their classes, or groups.

Best arthritis drugs

Nomination a place Name of product price
NSAIDs 1 Meloxicam (Movalis, Amelotex, Arthrosan, Genitron) 520 rub
2 Nimesulide (Nimesil, Nise, Nemulix, Nimulide, Prolide) 624 rub
3 Ketorolac (Ketanov, Dolak, Ketokam) 226 r
Hormonal intraarticular preparations 1 Betamethasone (Diprospan) 303 rub
Advanced treatment for severe arthritis 1 Penicillamine (Cuprenyl) 1 370 rub.
2 Methotrexate 314 rub
3 Leflunomide (Arava, Ralef, Elafra) 868 rub
4 Sulfasalazin-EN 329 rub

NSAIDs

NSAIDs are the main and almost indispensable group. medicines. They fight like symptoms listed above, and block the mechanism of inflammation, inhibiting a special enzyme – cyclooxygenase. If the medicine selectively blocks type 2 cyclooxygenase, then this remedy called a selective drug. It is safer acts selectively and causes fewer side effects, characteristic of older, “non-selective” drugs from this groups. As a rule, all anti-inflammatory non-steroidal drugs act on three “whales” of inflammation:

  1. temperature, or fever (antipyretic);
  2. pain;
  3. inflammation itself as a pathophysiological process.

Antipyretic properties are not interesting to us, since with arthritis rarely there is a general increase in temperature. Therefore, funds like Aspirin, Paracetamol, Ibuprofen are of little use in acute and chronic arthritis. But drugs that selectively stop pain that reduces swelling, redness and restores function, very appropriate. The most popular ones are listed below.

Meloxicam (Movalis, Amelotex, Arthrosan, Genitron)

Popularity Rating: 4.9

Movalis

Movalis is a highly effective German drug that Available in ampoules for intramuscular administration, and in tablets. In acute arthritis, especially with rheumatic or systemic character, first in the first day the drug is used intramuscularly, in parenteral form, and then move on pills for maintenance therapy. It goes without saying that if we are talking about acute infectious, or purulent arthritis, then treatment should be started with antibiotics and antibacterial drugs, and not with the relief of secondary inflammation.

Movalis relieves pain well, reduces temperature, inhibits synthesis of prostaglandins. It is shown, except for acute and chronic arthritis, with pain in the lower back, with protrusions and hernias of the disc, with rheumatoid arthritis and with ankylosing spondylitis, or disease Ankylosing spondylitis. It is usually prescribed for acute pain 1 15 mg tablet once daily. After achieving the effect of dose halved. The maximum dosage should not exceed 15 mg per day, that is, one tablet is the maximum daily dose. Produced by Movalis is a Berlin-chemie company, and the cost of packaging is 10 15 mg tablets is from 370 to 540 rubles. The cheapest domestic analogue of the company Pranafarm will cost from 43 rubles. before 100 rubles. That is, the domestic analogue is 16 times cheaper original drug. We hope that the quality of treatment still not 16 times worse.

Advantages and disadvantages

This is a highly active drug, and although it is selective, but still you need to take it as short as possible, and immediately reduce the dose. It is contraindicated, like many NSAIDs, with a combination of nasal polyposis with bronchial asthma and intolerance aspirin. The main contraindications are an active stomach ulcer, acute erosive gastritis, Crohn’s disease, or ulcerative colitis, severe liver damage, threatening the stomach bleeding, pregnancy, lactation and age up to 12 years. At side effects such as headache and gastrointestinal upset, interact with other drugs that need to be considered when destination.

Nimesulide (Nimesil, Nise, Nemulix, Nimulide, Prolide)

Popularity Rating: 4.8

Nimesulide (Nimesil, Nise, Nemulix, Nimulide, Prolide)

Nimesulide is one of the few drugs from the NSAIDs group, which is not available in parenteral ampoules. More often total – these are powders for solution in water and ingestion, tablets, as well as various creams and gels. One means shown with joint pain, arthritis and back pain, even with muscle and toothache pain and soft tissue injuries – is Nimesil. He has an action softer than Movalis. He not only fights inflammation and anesthetizes, but also helps to lower the temperature, which can be useful for colds. The drug can even be used with painful periods, and although after its withdrawal the symptoms again renew, but as part of complex therapy, it can be indispensable.

It is advisable to use Nimesil and its analogues in one package twice a day, the duration of admission should not exceed 2 weeks. The same company Berlin-Chemie produces Nimesil, and one package of 30 bags designed for such a two-week course will be cost from 600 to 750 rubles. Domestic company bags Marbiopharm can be purchased at a price of 250 to 590 rubles, but the most tablets of the same name are cheap. Even the dosage in 20 pieces are sold in pharmacies at a price of 40 rubles, and even below.

Advantages and disadvantages

The contraindications for taking Nimesil are the same as for Movalis. It is not recommended in case of severe coagulation disorders, with alcoholism and drug addiction. It is also contraindicated in pregnant and lactating mothers, and may cause characteristic NSAIDs are side effects of which nausea is most common, diarrhea or even vomiting. As in the previous case, any nimesulide it is necessary to apply the minimum effective doses and the minimum short course. Also, this drug is undesirable to combine with other drugs from the NSAID group.

Ketorolac (Ketanov, Dolak, Ketokam)

Popularity Rating: 4.7

KETOROLAK (KETANOV, DOLAK, KETOKAM)

Unlike the two drugs described above, ketorolac, or Ketanov, has a particularly pronounced analgesic focus. It doesn’t have a good effect on general inflammation, practically does not lower the temperature, but then acute pain after it application is significantly reduced, or even completely goes away. The ability of Ketanov and his analogues to anesthetize is approaching that of narcotic analgesics and Tramadol. Subject to him even severe toothache, and pain after surgery. The drug is a derivative of acetic acid, at a very Intense pain is applied intramuscularly, but more often used in tablets, that’s enough. It could be considered ketorolac is the most powerful painkiller of all others funds of this group.

It is necessary to use the medicine in tablets, one tablet daily, maximum daily dose for very severe pain in joints should not exceed 40 mg, and the duration of the course should not exceed five days, regardless of the dose. Thus, Ketorolac and its analogues are not a means for long-term treatment, and a drug for emergency treatment. All analogues are very inexpensive, so Indian Ketanov can be purchased at a price of 40 up to 55 rubles., in the package of 20 tablets.

Advantages and disadvantages

Ketanov has a huge, significant advantage in the form of a powerful analgesic effect, and the Ministry of Health of the Russian Federation receives huge and fat minus, because Ketanov over-the-counter in the pharmacy you will not be sold, although it does not affect opioid receptors, and does not have nothing to do with drugs. Apparently, if you have a strong dental or joint pain, then you must first beg for the recipe therapist, although more recently this drug could to get as a lifesaving pain medication is quite affordable. what Regarding the remaining disadvantages, then this is a standard set contraindications, including pregnancy, lactation and age under 16 years old, and the same set of side effects. Very good plus is a low price, but this plus is immediately lost due to complete inaccessibility of the drug in the free market.

Chondroprotectors

The section on chondroprotectors will not contain specific names of drugs, and is created only for general information, because they are “not working.” Chondroprotectors, i.e. substances from which cartilage consists of, protect it from destruction and are structural components of normal cartilage. Their man gets from synovial fluid because cartilage does not have blood vessels. Including cartilage of a joint affected by arthritis. These substances are chondroitin sulfate and glucosamine.

Chondroprotectors are all OTC drugs that considered nutritional supplements, but none of these drugs is proven effective in neither acute nor chronic arthritis, nor in degenerative degenerative processes.

The thing is that chondroprotectors in the digestive tract split into elementary components, which in their own way quantity and quality are no different from the same nutrients, which are formed in the intestines after eating ordinary jelly and jellied meat and fish dishes. Therefore, the reception chondroprotectors, for example Elbona, Alflutop, Inoltra not justified. If chondroprotectors are used intramuscularly, then this will not lead to the desired result, since the cartilage does not have vessels and will not receive these ingredients.

Therefore, manufacturers of chondroprotectors go for some tricks. So, the drug Teraflex Advance will help, but only just because, in addition to components that supposedly protect the articular cartilage, non-steroidal added anti-inflammatory drug ibuprofen.

Hormonal intraarticular preparations

But what if intramuscular and tablet preparations from the group of non-steroidal anti-inflammatory drugs not help? Then, with special indications, hormonal means, and when it comes to intra-articular injections, then, before of all, hormones are meant.

Betamethasone (Diprospan)

Popularity Rating: 4.9

Betamethasone

The most famous and widely used glucocorticosteroid for topical application is betamethasone. It is introduced as sterile suspension. It is a fairly strong glucocorticosteroid hormone, which is used in the form of intraarticular and periarticular injection. This drug is administered intramuscularly at a dose of 1 to 2 ml, and intraarticularly. Intra-articular administration in a dose of 0.5 up to 2 ml quickly and permanently eliminates pain, restores joint mobility, and the effect of just one injection can be long: up to 1 month, and even longer.

The well-known company Schering-Plow produces the drug Diprospan from Belgium, and you can buy the drug in the form of one small packaging in 1 ml, which may be enough in case of damage to small joints on four, joints, and in the case of a large joint – on one joint. The cost of such packaging ranges from 230 to 300 rubles. There is an analogue, Betaspan depot, Ukrainian production. Here, in the package will no longer be one ampoule, but five, at a price from 450 to 500 rub for packing. Accordingly, the value of this tax will be about 4 times cheaper if we consider the price of one ampoules.

Advantages and disadvantages

Plus Diprospana – in fast and long action, western quality, low price. However, this drug cannot be used. intravenously and subcutaneously, but it is undesirable to prescribe it immediately, after all, this is a strong, reserve medicine. Like any glucocorticosteroid it can cause an increased output of potassium from body, sodium retention and edema, weight gain, rise blood pressure and osteoporosis. With prolonged use, he can induce steroid diabetes, amplification of various manifestations of gastritis, exacerbation of gastric ulcer, and others complications and side effects characteristic of glucocorticoids.

Diprospan is contraindicated in the presence of acute infectious arthritis because, as mentioned above, infectious arthritis not treated with pathogenetic agents that affect inflammatory mechanism, and by means of etiotropic therapy, that is affect the immediate cause of arthritis – pyogenic flora.

Advanced treatment for severe arthritis

But there are such forms of arthritis when you need to be treated all your life, and taking drugs should be long. The tasks of these medicines are already others – affect the autoimmune process, reduce speed cell division, and thereby eliminate the inflammatory symptomatology. Just fighting inflammation, by blocking cyclooxygenase and rupture of the inflammatory cascade are no longer here get along. Such medicines are called basic medicines, and belong to the classes of complexing agents, cytostatics and immunosuppressants. Nobody will prescribe such medicines a patient with symptomatic arthritis that can be treated in other ways, such as fighting infection with tuberculosis arthritis or a rational regime of work and rest when professional inflammation of the joints. Basic funds are assigned in those systemic processes where patients can be given disability. The classic diagnosis is severe, progressive forms of rheumatoid arthritis, or ankylosing spondylitis (ankylosing spondylitis). Let’s list the best known drugs. from the group of basic drugs.

Penicillamine (Cuprenyl)

Popularity Rating: 4.9

PENICILLAMINE (KUPRENIL)

Penicillamine (not to be confused with penicillin!), Which is sold under by the commercial name Kuprenil, available in tablets, and refers to complexing compounds. That means he forms large molecular structures with atoms of copper, iron, cobalt, calcium and other trace elements. The medicine belongs to specific anti-rheumatic drugs.

Penicillamine is indicated for severe forms of rheumatoid arthritis, in the presence of systemic scleroderma, as well as disease Wilson-Konovalov, when too much accumulates in the body copper, and it needs to be bound and removed from the body. Shown Cuprenyl and in severe poisoning with metals, such as lead, or mercury. The medicine is used only as directed by a rheumatologist, half an hour before meals or after meals two hours if there is such the diagnosis of rheumatoid arthritis.

The starting dose begins with 250 mg per day, then the special dose the pattern slowly rises by half until a significant improvement, and then the dose is gradually reduced. Thus, achieve the minimum effective dose. If the medicine did not help within 6 months from the start of treatment, then this tool is recognized ineffective. Usually, the maintenance dosage is 600-750 mg a day. The drug is produced in tablets of 250 mg, in a bottle of 100 pills. Produced by Cuprenil in Poland pharmaceutical company Polfa and packaging costs an average of 1300 rubles, which is not cheap, given the duration of use.

Advantages and disadvantages

Like any serious drug, Cuprenil is contraindicated in renal failure in children, pregnant and lactating women, in case of agranulocytosis in the blood, and with renal insufficiency. Kuprenil “does not like” combinations with cytostatics. Unpredictability can be considered a big minus, about 30% patients, the medicine may be ineffective, but it will known only a few months after the start of treatment. After all, this drug immediately “does not work”, and even after a week or two after the start of treatment it is impossible to say whether he will help or not.

In addition, Cuprenyl can cause a large number of side effects such as vomiting and stomatitis, skin rash and taste distortions, eosinophilia and interstitial pneumonitis. Assigning Kuprenil, you need to remember that he is an antagonist of vitamin B6, and therefore with prolonged treatment may cause pyridoxine deficiency and disorders of the function of the peripheral nervous system, up to polyneuritis, which disappears after discontinuation of treatment.

Methotrexate

Popularity Rating: 4.8

Methotrexate

Methotrexate is the next basic cytostatic drug, which is used for various forms of arthritis, including severe rheumatoid arthritis, psoriatic arthritis. Besides, it is indicated for various malignant neoplasms, lymphogranulomatosis. It belongs to folic antimetabolites. acid, therefore, the patient is required while taking methotrexate should receive fairly high doses of folic acid to avoid complications, according to certain schemes. It is assigned the medicine is also according to special schemes, and it really slows down progression of rheumatoid arthritis.

Methotrexate is available in 5 mg tablets, and one of the most renowned and effective is Austria’s methotrexate Ebeve Farm. 50 tablets will cost from 300 to 380 rubles.

Advantages and disadvantages

Methotrexate can cause both early and delayed side effects. Various gastrointestinal tracts develop early symptoms, possibly the development of ulcerative stomatitis of the oral mucosa, there is a headache. For late, or delayed side effects, they experience up to a third of all patients. it the development of anemia, a decrease in white blood cells in the blood, a drop in platelets. 1% of patients suffer from drug pneumonitis, and this is severe a complication that can even be life threatening. Significant decreased immunity with methotrexate leads to the development of opportunistic infections, a fungal infection occurs, and even pneumocystis pneumonia. Methotrexate is harmful to the liver, therefore, during treatment, it is necessary to monitor the indicators liver enzymes.

Leflunomide (Arava, Ralef, Elafra)

Popularity Rating: 4.7

LEFLUNOMID (ARAVA, RALEF, ELAFRA)

Arava is a modern immunosuppressant that also refers to basic drugs. This medicine is shown in the first turn, for rheumatoid, and secondly – for severe psoriatic arthritis. Arava is available in tablets, and at the beginning 100 mg is taken daily for 3 days, and then transferred at a maintenance dosage in a small dose, from 10 to 20 mg a day. As with Cuprenil, the initial therapeutic effect appears no earlier than a month and a half after the start of the reception, and in case of successful therapy, he feels better and better, such a therapeutic effect can increase within six months, gradually reaching a maximum.

The company Sanofi Aventis releases this tool. One pack of 30 tablets of 10 mg will cost from 1200 to 3500 rubles., This enough for a month of maintenance therapy. If the patient is only begins treatment, then during the first three days he just consumes the entire bottle as it takes 10 tablets daily. But there is a way out – this is domestic leflunomide, which is produced, for example, by Canonfarm Production: one of the same packaging will cost less than 1000 rubles, within 950 rubles.

Advantages and disadvantages

Like all basic drugs, it is contraindicated in pregnant women, lactating and in persons under 18 years of age, you can not take Arava in severe impaired liver and kidney function, with severe infections, leukopenia, inhibition of bone marrow function and in severe immunodeficiencies. In addition, it has an embryotoxic effect. action, and if the man taking this medicine will conceive child, then he should be warned about the high risk of occurrence intrauterine deformities.

The drug also produces significant side effects, starting from diarrhea and nausea to tenosynovitis and possible rupture of ligaments, and hair loss. The white blood cell count drops in the blood, anemia develops, sometimes allergic reactions occur. therefore taking such medications is necessary only under the supervision of specialists and analysis data.

Sulfasalazin-EN

Popularity Rating: 4.6

Sulfasalazin-EN

Sulfasalazine is a medicine that rheumatologists know a long time ago. They take advantage of its pronounced side effect, since it is not a “pure” anti-inflammatory agent. On the in fact, this is a cure for an intestinal infection from the group sulfonamides, but it also has a pronounced anti-inflammatory effect when it accumulates in the walls intestines, and releases its special metabolites.

Therefore, they especially like to use this medicine gastroenterologists, in the treatment of ulcerative colitis, which also relates to connective tissue diseases. Wide sulfasalazine is also used for rheumatoid arthritis, including – in its juvenile form.

In case of rheumatoid arthritis, an adult is prescribed 500 mg sulfasalazine tablet once daily for the first week, during the second week – the dose doubles, and in during the third week, the dose is 1.5 g per day, that is, three pills. The course of treatment is long, up to six months, with a constant specialist supervision. Sulfasalazine is an inexpensive drug: so, Krka offers a pack of 50 tablets of 500 mg each at a price from 230 to 450 rubles., and the domestic company Ozone sells its sulfasalazine in pharmacies at prices up to 200 rubles.

Advantages and disadvantages

Sulfasalazine is not a basic drug, so it milder contraindications. In addition to severe liver disorders and kidney, this is lactation, anemia, hypersensitivity to sulfonamides and children under 5 years old. The remedy also causes some side effects from various organ systems, stains urine in a bright yellow color, and is able to stain yellow color is also soft contact lenses. With an overdose, it is possible the appearance of nausea and vomiting, sulfasalazine reduces digestibility folic acid, so you also need to add it during treatment.

Modern monoclonal antibodies

Finally, in conclusion of this review, it is necessary to recall modern drugs, for the production of which modern molecular genetic technologies. The result is exactly the same, or monoclonal antibodies that special microorganisms help a person, for example, this production strains (races) of special yeast.

But in order for yeast to start producing, in addition to alcohol, monoclonal antibodies, in their genetic code, in their hereditary information must be introduced specific genes, nucleic acid sites acids that are artificially formed, and which previously have yeast did not occur. To create such an artificial gene, which encodes the creation of proteins of the desired antibodies, is very necessary hi-tech industry. Moreover, this genome should be not just created, it is implanted in a yeast cell, and then propagated and support this clone. After that the produced antibodies collected in “pure form”. Thus, the yeast becomes suppliers of an extremely important product, peculiar “medical animals.”

There are several known drugs that are used in rheumatology, including for the treatment of arthritis. This is Remicade and his analogues that inhibit tumor necrosis factor (TNF), and belong to immunosuppressants. This is rituximab, or MabThera. MabThera is an antitumor drug that changes function. B-lymphocytes, and is used in the active form of severe rheumatoid arthritis. This is a drug like Orencia, or a blocker. stimulation of T-lymphocytes. The latter drug is also used for improving the activity of adult patients with severe active rheumatoid arthritis.

It should be recalled that all of these drugs assigned only when the patient does not tolerate basic funds, or does not respond to them actively enough. Such There are quite a few situations, because many basic drugs are aggressive, and cause a large number of side effects, for example, the same methotrexate.

All monoclonal antibodies are usually administered intravenously as infusions, and their cost is very, very high, so for many of them, patients need to literally fight with officials, despite the fact that many of them should be given to the patient is free. So, the cost of the cheapest infliximab (generic Remicade) is from 11 to 26 thousand rubles per bottle, and in case of Remicade, that is, the original means, the price may reach 53 thousand rubles. MabThera also stands in the range of 13 up to 45 thousand rubles, and when it comes to a solution for subcutaneous administration with a high dosage, the cost can reach up to 120 thousand rubles. Orencia, or abatacept, also costs quite expensive, and an interleukin receptor blocker, or Actemra, can also in its price go up to several tens of thousands of rubles.

Why are these drugs so expensive? First of all, they are very difficult to receive, even the most perfect is not enough for this pharmaceutical production, it’s molecular genetic, biotechnological production. Monoclonal antibodies act very selective, and therefore, although they have side effects, but nevertheless, the treatment process can be controlled with a high level predictions.

That is why all these modern tools are extremely effective in patients with severe arthritis and high risk fast disability monoclonal antibodies if not stop this process, they can still significantly delay disability period, for example, by doubling it slower. Therefore, if according to statistics a person has disability occurs after 7 years, then when using monoclonal antibodies he will be as much as 14 years, and maybe longer, capable of self-service and active life. Believe me, this is not a short time at all.

Popularity rating based on analysis of demand data service wordstat.yandex.ru.


Attention! This rating is subjective, not advertising and does not serve as a guide to the purchase. Before the purchase consultation with a specialist is necessary.

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