10 best soothing pills

Review of the best according to the editors. About the selection criteria. The the material is subjective, is not advertising and is not serves as a guide to the purchase. Before purchase is needed consultation with a specialist.

Contrary to a common phrase, not all diseases are from nerves. But I have to admit, the level of stress in life modern man literally rolls over. Consequences – insomnia, high blood pressure, unexplained anxiety, decreased immunity. And this is not to say that a “nervous” person rarely able to keep emotions to himself, “discharging” to loved ones and supporting the cycle of stress in society.

The trouble is that the popular “don’t be nervous” and “take yourself” tips in hand “in practice are completely useless. Stress, anxiety, negative emotions trigger a complex chain in the body biochemical interactions, the release of special hormones, neurotransmitters – substances that alter the activity of the nervous system. It is impossible to interrupt chemical reactions by willpower in principle. But sedatives successfully cope with this.

When rating the best soothing pills, we turned attention, first of all, to affordable medicines that do not require regular monitoring by a doctor during use. Those who need “heavy artillery, “you will have to consult a specialist: a neurologist or to the psychiatrist.

Rating of the best sedative pills

Nomination a place Name of product price
Best Soothing Pills Based on Herbal extracts 1 Hypericum Extract 326 rub
2 Persen 218 RUB
3 Novo-passit 199 rub
Best sedative pills for children 1 Glycine 33 rub
2 Phenibut 40 rub
3 Magne B6 480 rub
The best synthetic sedatives 1 Afobazole 378 RUB
2 Adaptol 608 rub
Best Soothing Supplements 1 Tryptophan 765 rub.
2 Gamma Aminobutyric Acid 1 040 rub.

Best Soothing Pills Based on Herbal extracts

Herbs – the first pharmacy of mankind. But herbal remedies, that is, the dried parts of the plants themselves have some disadvantages. Firstly, the content of useful substances in them can vary greatly depending on the place and time of growth, collection time, environmental conditions. Therefore, the result is not always predictable. Secondly, in plants, in addition to useful harmful substances may appear: lead from the soil, if plants collected by the “grandmother” near the freeway, pesticides that process the fields. Therefore, modern pharmacology does not use herbs by themselves, and extracts of nutrients – extracts plants. They can be brought to standard doses and get predictable result of action.

Talking in our rating about medicines based on plant extracts, we want to remind you: “herbs”, although in general safer than “chemical” drugs, they also have limit dosages, contraindications and side effects that you definitely need consider.

The effect of taking any herbal preparations is cumulative, so that it can manifest itself, it will take 2 to 3 weeks of regular reception. Therefore, before making conclusions about whether or not it helps the medicine helps, you need to wait, and if the stress is acute and requires some urgent measures, it is better to use tablets with synthetic active substance.

Hypericum Extract

Rating: 4.9

Deprim Forte

Trade names: Negrustin, Deprim Forte, Neuroplant.

The fact that St. John’s wort acts like the well-known antidepressants by regulating the amount of serotonin in the nervous system, it became known in the 80s of the last century. Held later studies have confirmed the soothing properties of this herb. Active active ingredients – hypericin, pseudohypericin and hyperforin – improve the functional state of the nervous system, have a psychostabilizing effect. After taking the tablets on the basis of hypericum perforatum extract is gradually increased mood, psychoemotional background is leveled, declining anxiety. Hypericum active substances normalize sleep, restore activity and performance, reduce such bodily manifestations of anxiety and depression as jumps in arterial pressure, sweating, weakness.

Unlike many sedatives, St. John’s wort extract does not causes drowsiness, and it can be used by those who drive or working in conditions requiring concentration and quick reactions.

St. John’s wort extract can be taken 1 to 3 times a day, in depending on well-being. Among the side effects, the most frequent – allergy, possible discomfort in the abdomen (dyspepsia).

St. John’s wort increases sensitivity to sunlight, therefore taking it in the summer is better to avoid long exposure to the sun, and if this is not possible, use sunscreen. is he enhances the effect of traditional antidepressants, so this combinations are best avoided. Also, it is not recommended to take St. John’s wort simultaneously with theophylline, cyclosporins, anticonvulsants. Hormone women contraceptives, you need to keep in mind that St. John’s wort weakens them action, therefore, during its use it is better to use additional protection against unwanted pregnancy.

Not recommended for pregnant women, children under 12 years.


  • natural composition
  • high efficiency, comparable in the initial stages of depression with “heavy” antidepressants.


  • increases sensitivity to the sun.


Rating: 4.8


Contains extracts of valerian, lemon balm and mint. Vegetable components are selected so as to enhance each other’s action. Behind account of lemon balm and mint, which are not only soothing, but also light antispasmodics, optimal in situations where stress is accompanied the so-called psychosomatic manifestations – abdominal pain, “bear disease”, headaches, slight increase blood pressure. For the same reason, persen is not worth it. use for people prone to hypotension and fainting – antispasmodic effect extends to smooth muscle vessels, which can excessively reduce blood pressure. Not recommended also with gallstone disease – mint has a weak choleretic action, because of which the stones can “move”.

Daily dosage of Persen: 2 – 3 tablets, you can take them evenly throughout the day, and one-time before bedtime, if the main complaint is difficulty falling asleep. If the minimum dosage does not help, you can increase the number of taken capsules up to 12 per day – of course, in this case, use them It should not be simultaneously, but during the day.

Possible side effects – an allergic reaction to herbal components of tablets with prolonged use persena possible constipation, again due to antispasmodic properties lemon balm and mint.

Due to lack of safety data, do not use persen to pregnant, lactating and children under 12 years old – according to the obvious reasons to conduct a study on these patient groups impossible.


  • natural composition
  • safety of use.


  • relatively high price for common extracts herbs.


Rating: 4.7


Contains seven medicinal extracts that mutually potentiate each other’s action and the semi-synthetic substance guaifenesin.

Plants that are part of Novo-Passita:

  1. valerian,
  2. Melissa,
  3. St. John’s wort
  4. hawthorn,
  5. passionflower (passion flower),
  6. hop,
  7. black elderberry.

Hawthorn and lemon balm, in addition to sedative (sedative) actions have a slight hypotensive effect, i.e. ability to lower blood pressure. Passionflower and hops reduce anxiety and improve sleep. Black elderberry has soothing and restorative properties.

Guaifenesin is a semi-synthetic substance created on the basis of Guaiac wood extract. Traditionally used as expectorant, but over time it turned out that he has anxiolytic, that is, anti-anxiety properties, as well as enhances the calming and hypnotic effect of other drugs. Actually, for this purpose he was added to Novo-Passit.

Recently, evidence has emerged that hop extract contains including phytoestrogens – plant substances with action, similar to the effect of female sex hormones. Therefore Novo-passit in First of all, it is suitable for women in age, to correct the effect hormonal changes in the emotional sphere. It may also be useful for headaches and migraines caused by stress, insomnia.

Take a tablet 3 times a day.

Among the side effects, the most common are allergies and increased drowsiness. Therefore, Novo-Passit is not recommended for people driving a car or those whose work requires attention and quick reactions.

Contraindicated under the age of 12 years.


  • complex composition.


  • not recommended for those driving
  • prolonged use may cause constipation.

Best sedative pills for children

In this section of the rating, we have included tablets that are allowed to use in children older than three years. The fact is that according to Ministry of Health experts creating the criteria according to which drugs are registered, under the age of three years any tablets are contraindicated in principle, since it is difficult for kids swallow them and there is a considerable risk that the child chokes. Because for younger age, there are all kinds of drops, syrups, herbal teas. Soothing tablets can be used only after three years.

But before you clutch at the medicine, especially when it comes to kids, it is better to start with time-tested non-medication methods. Soothing baths with valerian are good for babies, motherwort or mint: the skin of babies is able to absorb medicinal substances. Older children fit warm baths with sea ​​salt. You can still put flavored in bed pads inside which the same soothing herbs are sewn. Of course, all this is permissible only if the child has no allergies and he does not suffer from bronchial asthma – with this disease herbal medicine in any form is contraindicated.

Do not prescribe medication to the baby yourself, show it doctor: perhaps the cause of concern is a serious illness, not stress. If the reason for his concern is still external factors: adaptation to kindergarten, overwork, excess The following pills may help.


Rating: 4.6


A medicine tested by generations of moms. Strictly speaking, this is not a sedative, and nootropic is a drug that normalizes processes in the central nervous system and increases mental working capacity. Moreover, it has the following properties:

  1. improve your mood
  2. facilitate falling asleep and normalize duration and depth sleep
  3. reduce psycho-emotional stress,
  4. reduce aggressiveness
  5. improve social adaptation.

Glycine tablets should not be swallowed, but dissolve behind the cheek or under the tongue. The medicine has a sweet taste, so children usually Do not mind the reception.

Healthy babies as a sedative glycine 1 tablet is prescribed 3 times a day, the course of use is from 2 weeks up to a month. For sleep disorders, you can give 1 tablet per night.

The drug is contraindicated in case of individual intolerance.


  • time-tested tablets
  • safety of use.


  • need to be absorbed, not swallowed.


Rating: 4.5


This medicine also applies to nootropics: it helps adapt to mental stress and improves metabolic processes in the central nervous system. But other than that, phenibut reduces anxiety, tension, anxiety, normalizes sleep.

Reduces the severity of headaches caused by stress, eliminates weakness, psycho-emotional instability. Indirect an indicator of how effectively phenibut lowers stress, it can serve as one of the medicines cosmonauts included in the first-aid kit.

Phenibut is prescribed to children not only as a sedative, but also with comprehensive treatment for stuttering and ticks.

The likelihood of side effects is small. Drug may cause drowsiness. Another variant of adverse events is paradoxical (reverse) reaction to the remedy, when after it reception there is a headache, dizziness, irritability. Allergic reactions are possible.

Phenibut is contraindicated in pregnant and lactating women under the age of 2 years old.

Released by prescription.


  • effectively reduces high stress levels while maintaining activity and human performance.


  • prescription drug.

Magne B6

Rating: 4.4


Restores the level of magnesium in the body – a mineral that vital for the functioning of all body cells – and pyridoxine – a vitamin that regulates the functioning of the nervous system. Natural magnesium is found in wheat bran, pumpkin and sesame seeds, pine and walnuts, spinach – in a word, foods that are not often included in the diet of children. Therefore deficit this mineral in the body is not uncommon. In addition, its development contributes to dysbiosis and taking antibiotics, which is also not uncommon in children’s age.

Magnesium and B6 regulate the transmission of nerve impulses, eliminating increased irritability, fatigue, restoring sleep.

Children over 6 years of age are prescribed 4 to 6 tablets per day, which need to use in 2 – 3 doses.

The drug is contraindicated in severe renal insufficiency. Safety during pregnancy and breastfeeding not established.

When taking Magne B6, you need to remember that magnesium absorption blocked by calcium, so it can not be taken simultaneously with dairy products or multivitamins containing calcium.


  • compensates for the deficiency of magnesium and vitamin B6,


  • can not be combined with multivitamins, and food, containing calcium.

The best synthetic sedatives

In this section of the rating, we included funds of various pharmacological groups that somehow regulate the work of the nervous system. Unlike herbal preparations, such tablets show the necessary result in the first days of admission.


Rating: 4.3


Reduces anxiety and has a mild stimulating effect. Eliminates such manifestations of nervousness as:

  1. irritability,
  2. tearfulness
  3. timidity
  4. insomnia
  5. heartbeat
  6. feeling of lack of air
  7. memory impairment,
  8. inability to concentrate.

Manifesting within a week after the start of use, effects afobazole peaks by the end of the month and 2 more remain weeks after the end of the reception.

Afobazole 10 mg 3 times daily is recommended. course duration from 2 weeks to 3 months, as needed. Short courses can be assigned to women in the second half menstrual cycle to reduce the manifestations of premenstrual syndrome.

Of the side effects, allergic reactions are possible.

Afobazole is contraindicated in pregnancy and lactation, in under the age of 18 years.


  • can be applied in relatively short courses,
  • can be used for PMS,
  • over-the-counter.


  • It is not recommended to combine with alcohol.


Rating: 4.2


Regulates the ratio of mediators – special substances that activate or inhibiting various functions of the central nervous system, contributing to the normalization of the emotional state. Eliminates unmotivated anxiety, anxiety, fear, reduces irritability, reduces internal emotional stress. Himself By itself, sleep disturbances do not eliminate and does not contribute to falling asleep, but enhances the effect of sleeping pills.

Improves attention and mental performance.

The recommended dosage is 500 mg three times a day. Can take both short courses and for 2 to 3 months, of necessity. Adaptol is combined with any other medicines, including “heavy” tranquilizers, antidepressants, allowing you to enhance their action and reduce dosage.

Side effects are minimal – allergic reactions.

The drug is not recommended during pregnancy and children since safety has not been studied.


  • combined with any medication
  • fast onset of effect.


  • prescription drug.

Best Soothing Supplements

In this section of the rating, we included biologically active additives that contribute to the normalization of processes in the central nervous system. Their sedative effect is somewhat similar to the drugs. plant origin – develops relatively slowly, but stored after the end of the use of funds. Like Supplements are mild and rarely cause side effects.


Rating: 4.1


This is an essential amino acid from which the body produces Serotonin necessary for the normal functioning of the nervous system. Tryptophan, often called the amino acid of good mood should be ingested with food. Most of all him found in red and black caviar, hard cheeses, peanuts, almonds, cashews. In short, in products that are not available to everyone and not every day. Therefore, the need often arises additional administration of tryptophan.

Serotonin, which is produced from tryptophan, is often called “hormone of joy.” This substance creates stable good. mood, smooth positive emotional background. Participating in the synthesis melatonin, serotonin provides a healthy and full sleep.

Tryptophan can help with conditions such as:

  1. Depression
  2. increased anxiety
  3. increased irritability, aggressiveness,
  4. chronic fatigue syndrome
  5. premenstrual syndrome
  6. sleep disturbance.

Tryptophan has another interesting side effect: it reduces the need for sweets and reduces appetite, so it can be recommended separately to people prone to “seize” stress.

The daily dosage of tryptophan is from 500 mg to 2 grams, in depending on the general condition. To restore sleep, it should take at night, in all other cases – evenly over of the day. You need to start with minimal dosages, as with excessive the amount of tryptophan can cause side effects such as nausea. dry mouth, drowsiness.

In no case can you combine it with “pharmacy” antidepressants prescribed by your doctor – this can lead to excessive increase in serotonin levels in the blood.

Tryptophan can be purchased at pharmacies where the product is sold. Russian-made and foreign online stores.


  • softly and naturally regulates mood,
  • helps in the fight against excess weight.


  • cannot be combined with antidepressants.

Gamma Aminobutyric Acid

Rating: 4.0


Trade Names: Aminalon, GABA, GABA.

This is one of the most powerful inhibitory neurotransmitters of the central nervous system or, more simply – a substance that calms nerve cells. In addition, GABA improves blood circulation and normalizes metabolic processes in the brain. By the way, modern Doctors attribute the calming effect of valerian to the fact that increases the level of GABA in the brain.

The tool reduces the level of general anxiety, warns the appearance of panic attacks. Reducing the overall level of excitability, improves sleep, speeds up falling asleep. Reduces the manifestations of PMS. Helps to improve attention, memory. Has mild hypotensive act.

The initial dosage is 250 mg 3 times a day, with normal tolerance, you can increase the dose to 1.5 g per day.

Possible adverse events are nausea, fluctuations in blood pressure, feeling of heat.

Curious side effect: GABA stimulates hormone production growth. therefore, practicing bodybuilders often take it (in dosage up to 3 grams per day) to increase muscle mass and reduce the amount of adipose tissue.

GABA is contraindicated in pregnancy and lactation, while severe renal failure, under the age of 3 years.

The tool can be purchased in Russian pharmacies (according to a prescription doctor), and in foreign online stores in the form over-the-counter dietary supplement.


  • an overdose is impossible: the body effectively neutralizes excess substance
  • improves metabolic processes in the brain.


  • use with caution to those who are driving.

Attention! This rating is subjective, not advertising and does not serve as a guide to the purchase. Before the purchase consultation with a specialist is necessary.

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